摘要
丹参酮ⅡA(TanshinoneⅡA)是从中药丹参中分离提取得到的一种脂溶性的二萜醌类成分。药理研究表明丹参酮ⅡA在心血管疾病的治疗方面以及在神经保护和缺血再灌注损伤的保护方面发挥着明显的作用,其抗炎、抗氧化、抗肿瘤等多种生物学活性作用也扩大了丹参酮ⅡA应用范围。主要就丹参酮ⅡA药理作用及机制研究现状作综述,为丹参及丹参酮ⅡA的深入开发利用提供参考,以期丹参及丹参酮ⅡA可以发挥最大的药用价值。
Tanshinone ⅡA is the fat soluble diterpene quinone constituent separated and extracted from Chinese herbal medicine Salvia miltiorrhiza. Pharmacological studies showed that it plays an active role in the treatment of cardiovascular diseases, neuronal protection and the protection of ischemia reperfusion. Because tanshinoneⅡA has various biological activities, such as anti-inflammatory, antioxi- dant, anti-tumor, these actions could enlarge its range of applications. In this review, the pharmacological actions and the mechanism of tanshinoneⅡA were summarized to provide references for the further development and utilization of Salvia miltiorrhiza and tanshinoneⅡA, and to make the most of the medicinal value of Salvia miltiorrhiza and tanshinone ⅡA.
出处
《生物学杂志》
CAS
CSCD
2016年第6期91-94,共4页
Journal of Biology
基金
北京市教委面上项目(SQKM201411417014)
北京联合大学校级科研项目(ZK70201402)
关键词
丹参
丹参酮ⅡA
药理作用
研究前景
Salvia miltiorrhiza
tanshinone ⅡA
pharmacological action
research prospect
