摘要
目的：探讨老年帕金森病患者发生认知障碍的影响因素。方法将74例老年帕金森病患者按有无认知障碍分为观察组31例和对照组43例，统计两组临床资料并进行对比分析，对观察组认知障碍状况进行多因素Logistic回归分析。结果观察组帕金森病病程≥3 a、学历高中以下、从事体力劳动者构成比及汉密顿抑郁量表总分、血浆同型半胱氨酸水平均显著高于对照组（P＜0．05或0．01），血尿酸水平显著低于对照组（P＜0．01）。观察组认知障碍状况与患者帕金森病病程、职业性质、学历及血浆同型半胱氨酸水平显著相关（O R＝0．963、1．030、1．073、1．812，P＜0．05）。结论帕金森病病程长、受教育程度低、从事体力劳动者及血浆同型半胱氨酸水平升高是引起患者发生认知障碍的主要危险因素，临床上应有针对性地进行早期干预，以减少认知障碍的发生。
Objective To explore the factors influencing cognitive disorder of senile patients with Parkin‐sonian’s disease （PD） .Methods Seventy‐four senile PD patients were assigned to observation （n=31） and control group （n=43） according to whether they had cognitive disorder ,clinical data of both groups added up and contrastively analyzed ,and multiple logistic regression analyses of cognitive disorder status carried out in observation group .Results The constituent ratio of patients with PD course ≥ 3 years ,ed‐ucational backgrounds below senior middle school and engaging in manual work as well as the total score of the HAMD and plasma homocysteine levels were significantly higher （P〈0 .05 or 0 .01） and blood uric acid lower （P〈0 .01） in observation than control group .Cognitive disorder status was significantly related to course ,occupational quality ,educational backgrounds and plasma homocysteine levels （OR= 0 .963 , 1 .030 ,1 .073 ,1 .812 ,P〈0 .05） .Conclusion Main risk factors causing cognitive disorders of PD patients are longer course ,lower educational backgrounds ,manual work and heightened plasma homocysteine levels and purposeful early interventions should be given to them to lower the development of cognitive disorder .
出处
《临床心身疾病杂志》
CAS
2016年第6期94-96,共3页
Journal of Clinical Psychosomatic Diseases
关键词
帕金森
震颤麻痹
认知障碍
神经系统变性疾病
影响因素
早期干预
PD
paralysis agitans
cognitive disorder
neurodegenerative disease
influencing factor
early intervention
