摘要
目的研究百令胶囊联合氯沙坦对早期糖尿病肾病患者24 h尿微量白蛋白（urinary microalbumin,UMA）及脂代谢影响。方法选择2015年10月~2016年5月在宁波鄞州人民医院肾内科进行治疗的早期糖尿病肾病患者118例,按照随机抽签的方式分为观察组和对照组,对照组使用氯沙坦进行治疗,观察组在此基础上联合百令胶囊进行治疗。2组患者均治疗3个月后,观察2组患者UMA以及脂代谢的相关情况,并分析其治疗的效果。结果治疗后,观察组患者的UMA（125.00±44.00）mg/24 h与尿微量白蛋白排泄率（Urine albumer excretion rate,UAER,（54.64±17.31）μg/min水平均明显的低于对照组UMA（216.00±46.00）mg/24 h,UAER（67.42±21.86）μg/min,2组比较差异具有统计学意义（P〈0.05）;观察组的总胆固醇（total cholesterol,TC）为（6.15±0.75）mmol/L、甘油三酯（triglyceride,TG）为（2.34±0.48）mmol/L、低密度脂蛋白（low density lipoprotein,LDL-C）为（3.55±0.73）mmol/L,对照组TC（6.74±0.78）mmol/L,TG（3.01±0.41）mmol/L,LDL-C（4.06±0.64）mmol/L,观察组TC,TG和LDL-C的水平均明显的低于对照组,观察组高密度脂蛋白（high-density lipoprotein,HDL-C）（1.39±0.26）mmol/L水平明显的高于对照组（1.26±0.42）mmol/L,2组比较差异具有统计学意义（P〈0.05）;2组患者在经过治疗后,观察组的总有效率为89.7%,明显的高于对照组的总有效率75.0%,2组比较差异显著（P〈0.05）。结论百令胶囊联合氯沙坦治疗早期糖尿病肾病,能够有效减少UMA的水平,改善患者的血脂血糖水平,从而具有显著的治疗效果。
Objective To study the Bailing capsule combined losartan for UMA and lipid metabolism in patients with early diabetic nephropathy impact analysis. Methods 118 patients with early diabetic nephropathy from October 2015 to May 2016 in our hospital,according to the random lottery was divided into observation group and control group,control group using losartan treatment,observation group on the basis of the combination of Bailing capsule for treatment. Two groups of patients were treated after 3 months,observing two groups of patients with UMA and lipid metabolism related situation,and analyzes the effect of the treatment. Results The UMA（ 125. 00 ± 44. 00） mg /24 h and UAER（ 54. 64 ± 17. 31） μg / min were significantly lower in the observation group than in the control group UMA（ 216. 00 ± 46. 00） mg /24 h,UAER（ 67. 42 ± 21. 86） μg / min,2 group difference was statistically significant（ P〈0. 05）. The total cholesterol（ TC） of the observation group was（ 6. 15 ± 0. 75） mmol / L,triglyceride（ TG）was（ 2. 34 ± 0. 48） mmol / L,low density lipoprotein（ LDL-C） was（ 3. 55 ± 0. 73） mmol / L. The levels of TC（ 6. 74 ± 0. 78） mmol / L,TG（ 3. 01 ±0. 41） mmol / L and LDL-C（ 4. 06 ± 0. 64） mmol / L,respectively. The levels of TC,TG and LDL-C in the observation group were significantly lower than those in the control group,and high-density lipoprotein（ HDL-C）（ 1. 39 ± 0. 26） mmol / L was significantly higher than that in the control group（ 1. 26 ± 0. 42） mmol/L,the difference was statistically significant（ P〈0. 05）; Two groups of patients after treatment,the observation group total effective rate was 89. 7%,significantly higher than that of control group total effective rate 75. 0%,two groups are significant difference（ P〈0. 05）.Conclusion Bailing capsule combined losartan treatment of early diabetic nephropathy,can effectively reduce the levels of UMA,improve blood lipid in patients with blood sugar levels,which has significant therapeutic effect.
作者
黄佳媛
周参新
HUANG Jia-yuan ZHOU Can-xin(Departmene of of Nephrology, Ningbo Yinzhou People’s Hospital,Ningbo 315040,China)
出处
《中国生化药物杂志》
CAS
2016年第12期144-146,150,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
百令胶囊
氯沙坦
糖尿病肾病
尿微量白蛋白
脂代谢
Bailing capsule
losartan
diabetic nephropathy
the urine trace albumin
lipid metabolism
