摘要
【目的】分析妊娠期糖尿病(GDM)对双绒毛膜性双胎妊娠母儿结局的影响。【方法】分析2013年1月至2015年6月在中山大学附属第一医院住院分娩的329例双绒毛膜性双胎妊娠的临床资料,包括95例合并妊娠期糖尿病组(GDM组)及234例血糖正常组(对照组),比较两组母儿并发症的情况。【结果】GDM组孕妇年龄(32.2±3.5)岁明显高于对照组孕妇年龄(30.9±3.9)岁,差异有统计学意义(P=0.007),而孕前体质量指数、受孕方式、分娩方式两组差异无统计学意义;GDM组胎膜早破发生率(21.1%)高于对照组(12.4%),差异有统计学意义(P=0.036),而早产、胎儿生长受限、妊娠期高血压疾病、胎盘早剥、产后出血发生率两组比较无统计学差异。GDM组双胎不同一性发生率(3.2%)低于对照组(9.1%),差异有统计学意义(P=0.048),新生儿体质量、小于胎龄儿、新生儿呼吸窘迫综合征、新生儿低血糖、新生儿病理性黄疸、新生儿感染、围产儿死亡及双胎之一死胎发生率两组比较,差异均无统计学意义。【结论】妊娠期糖尿病没有增加双绒毛膜性双胎妊娠不良围产结局。
[Objective] To investigate the influence of gestational diabetes meIIitus on perinatal outcome in dichorionic twin pregnancy. [ Methods ] A total of 329 dichorionic twin pregnancy deliveried in the first affiliated hospital of Sun Yat-sen University between January 2013 and June 2015 were included in this study, and were assigned to two groups, including 95 cases complicated with gestational diabetes mellitus （GDM group） and 234 cases with normal glucose levels （non-GDM group）. We compared the pregnancy outcome of two groups. [Results] The maternal age in GDM group were higher than non-GDM group（32.2 ± 3.5 years vs 30.9 ± 3.9years, P = 0.007）. No differences were observed in pre-pregnancy BMI, mode of fertilization and mode of delivery between two groups. Significant increase of premature rupture of membrane was observed in GDM group than non-GDM group （21.1% vs 12.4%,P = 0.036）, whereas there were no differences in preterm birth, fetal growth restriction, pregnancy-induced hypertension, placental abruption and postpartum hemorrhage. Significant decrease of discordant twin was observed in GDM group than non-GDM group （3.2% vs 9.1%, P = 0.048）. No significant differences were observed in neonatal weight, small gestational age, neonatal respiratory distress, neonatal hypoglycemia, neonatal pathologic distress, neonatal infection, neonatal death and stillbirth in one of twin between two groups. [ Conclusion ] Gestational diabetes mellitus does not increase adverse perinatal outcome in dichorionic twin pregnancy.
作者
李珠玉
刘培培
祝彩霞
陈海天
王子莲
LI Zhu-yu LIU Pei-pei ZHU Cai-xia CHEN Hai-tian WANG Zi-lian(Department of Gynecology and Obstetrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510050, China)
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2016年第5期704-708,共5页
Journal of Sun Yat-Sen University:Medical Sciences
基金
国家卫计委公益性行业科研专项项目(201402006)
关键词
妊娠期糖尿病
双胎妊娠
围产结局
gestational diabetes mellitus
perinatal outcome
twin pregnancy
