摘要
采用手性流动相添加剂——脱氧胆酸钠拆分 1,1′-双萘基 - 2 ,2′-二氢磷酸盐手性化合物 ,筛选出含 3%异丙醇的 4 0 mm ol/ L 脱氧胆酸钠流动相为最佳条件 ,分离因子为 1.0 9,分辨因子为 2 .
A HPLC method for chiral separation of 1,1′ binaphthyl 2,2′ diyl hydrogenphosphate(1) was developed. Sodium deoxycholate (NaDC) was used as chiral selector. Optimum seperation condition was achieved in the mobile phase of 40 mmol/L in 3% isopropanol solution and at the detection wavelength of 254 nm. The selective factor of 1 was 1.09 , and the seperation factor was 2.94 .
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2002年第8期399-400,共2页
Chinese Journal of Pharmaceuticals
