摘要
目的探讨不同程度慢性阻塞性肺疾病稳定期患者血栓前状态的临床特点及意义。方法选取符合纳入及排除标准的新疆医科大学第一附属医院收治的慢性阻塞性肺疾病150例患者,按照肺功能结果分为轻度组(n=50)、中度组(n=50)、重度及极重度组(n=50)3组,同时随机选取50例我院健康体检者作为对照组(n=50)。比较分析各组患者的年龄、性别、民族等一般资料及凝血指标[血小板计数(PLT)、血红蛋白(HB)、凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)]的差异。结果各组间年龄差异有统计学意义(F=2.859,P<0.05),组间性别及民族分布差异无统计学意义(P>0.05)。轻度组、中度组、重度及极重度组与对照组的APTT(F=2.108,P>0.05)、PLT(F=2.230,P>0.05)、PT(F=2.487,P>0.05)比较差异无统计学意义。轻度组、中度组、重度及极重度组患者的HB(F=4.407,P<0.05)、D-D(F=70.403,P<0.05)、FIB(F=86.095,P<0.05)与对照组比较差异有统计学意义。中度组HB、D-D、FIB高于轻度组,重度及极重度组高于中度组且明显高于轻度组,差异有统计学意义;而轻度组、中度组、重度组及极重度组间的APTT(F=2.108,P>0.05)、PLT(F=2.230,P>0.05)、PT(F=2.487,P>0.05)比较差异无统计学意义。结论不同程度的COPD稳定期患者血栓前状态存在差别。COPD病情程度越重,血栓前状态越显著。
Objective To investigate the clinical characteristics and significance of prethrombotic states on patients with different degrees of chronic obstructive pulmonary disease （COPD）in stable period.Met-hods 150 cases with COPD patients treated in the First Affiliated Hospital of Xinjiang Medical University were divided into three groups, based on inclusion and exclusion criteria with lung function results, namely the mild group （n =50）,moderate group （n =50）,severe to extreme group （n =50）,and 50 cases healthy people from the hospital selected randomly as control group （n=50）.Comparative analysis of each patient′s general information （age,gender and ethnic）and coagulation indexes,such as Platelet＆amp;nbsp;count （PLT ）, hemoglobin （HB ）, prothrombin time （PT ）, activated partial thromboplastin time （APTT）,fibrinogen （FIB）,and D-dimer （D-D）were measured.Results There was difference in age be-tween the groups （P 〈0.05）,while no statistical significance in gender and ethnic between the groups. Compared with the control group,the levels of APTT,PLT and PT in the mild,moderate,severe to ex-treme groups were no statistical significance （all P 〉0.05）,while the levels of HB,D-D and FIB in the groups were statistical significance （all P 〈0.05）.And the levels of HB,D-D and FIB in different groups were increasing from mild to extreme degrees of COPD with statistical significance （all P 〈0.05）.Conclu-sion There were differences in different degrees of prethrombotic state of COPD patients in stable period, that is,the heavier of COPD,the more significance of prethrombotic state.
作者
安雯
克丽别娜.吐尔逊
李晗
迪丽努尔.乌甫尔
木叶沙尔.皮达义
AN Wen Kelibiena Tuerxun LI Han Dilinuer Upur Muyeshaer Pidayi(Department of Respiratory Medicine, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Chin)
出处
《新疆医科大学学报》
CAS
2017年第1期45-47,54,共4页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区自然科学基金(2015211C068)
