摘要
骨关节炎（osteoarthritis,OA）主要表现为病变关节的关节软骨退行性变、继发性骨质增生,可累及病变关节滑膜、关节囊和关节其它毗邻结构[1],涉及关节软骨的侵蚀、骨赘形成、软骨下硬化以及滑膜和关节囊的一系列生化和形态学改变的慢性迁延性疾病[2]。骨关节炎自被发现以来,其定义一直存在争议,osteoarthritis最初由John Spender于1886年讲到类风湿关节炎的更适合名称时提出，
Osteoarthritis（ OA） mainly manifests as articular cartilage degeneration, secondary osteoarthritis and chronic degenerative diseases involving the joint synovium, joint capsule and other adjoining structures of the joint. Its incidence and progress are more complex. In recent years, with the development of molecular biology, pathology and imaging, the understanding of OA has been deepening. Some factors such as biological stress, hormone metabolism, metal atoms, free radical imbalance and certain cytokines are also gradually considered to be closely related with OA. The imbalance of oxygen free radicals in microenvironment caused by dysfunction of mitochondria is considered to be one of the main causes for the development of OA. The imbalance of oxygen free radicals may aggravate mitochondrial damage under the low expression of antioxidant free radicals, making the microenvironment of oxygen free radicals beyond the self-regulated steady state. It is manifested as inflammatory mediator damage, genetic material damage, weakened repair, disorder of apoptosis and autophagy in the structure and time and weakened role of antioxidant free radical system under the microenvironment imbalance of oxygen free radicals. The series of changes based on microenvironment imbalances will continue through the online response to continuously express the damage effect, which is an important reason for chronic and persistent unhealing of OA. In this paper, under the microenvironment imbalance of oxygen free radicals, the effects of oxygen free radical imbalance on the occurrence and progress of OA are briefly reviewed.
作者
李红波
彭磊
LI Hong-bo PENG Lei(Department of Orthopedics, the Affiliated Hospital of Hainan Medical College, Haikou, Hainan, 570102, PRC)
出处
《中国骨与关节杂志》
CAS
2016年第12期939-943,共5页
Chinese Journal of Bone and Joint
基金
国家自然科基金(81460339)
关键词
氧自由基
自由基
骨关节炎
关节炎
关节疾病
Oxygen radicals
Free radicals
Osteoarthritis
Arthritis
Joint diseases
