摘要
目的探讨血清腺苷脱氨酶(ADA)、同型半胱氨酸(Hcy)、视黄醇结合蛋白(RBP)检测在肝硬化(LC)诊断中的临床应用价值。方法选取2014年1月-2015年12月间遂宁市中心医院肝胆科及消化内科收治住院的117例LC(按肝功能Child-Pugh分级,A级43例、B级39例和C级35例)患者作为研究对象,40例健康体检者(对照组)使用日立7600全自动生化分析仪,血清样本ADA、Hcy、RBP检测的结果进行回顾性分析。结果 LC组的A级、B级和C级中ADA和Hcy检测结果高于对照组,RBP检测结果低于对照组,差异有统计学意义或高度统计学意义(P<0.05或P<0.01)。LC组A级、B级、C级中随着肝功能损害程度的加重,ADA和HCY检测结果逐渐升高,RBP检测结果逐渐降低,差异有统计学意义或高度统计学意义(P<0.05或P<0.01)。A级中三项指标单项和联合检测的阳性检出率均高于对照组,联合检测的阳性检出率高于单项检测的阳性检出率,比较差异有统计学意义(P<0.05)。结论三项生化指标与肝细胞损害密切相关,可作为肝实质损伤程度的重要反映指标,联合检测提高LC早期诊断的阳性检出率,能为基层医院医生对LC的早期诊治、临床疗效及预后判断提供可靠的实验室依据。
Objective Discuss the clinical significance of serum adenosine deaminase（ADA）,Homocysteine（Hcy）,retinol binding protein（RBP）testing in the diagnosis of liver cirrhosis（LC）clinical application value.Methods Selected 117 cases of LC（according to liver function Child-Pugh classification,grade a 43 cases,grade B 39 cases and grade C35cases）were selected from January 2014 to December 2015 in the Central Hospital of Suining city.The patients were enrolled in the study.The patients were enrolled in the study,The results of ADA,Hcy,and RBP were retrospectively analyzed in 40 healthy subjects（control group）and healthy subjects（control group）on the Hitachi 7600 automatic biochemical analyzer.Results LC group Grade A,B and C levels ADA and Hcy in were higher than those in the control group,the RBP test results were lower than the control group,the difference was statistically significant or highly statistically significant（P〈0.05 or P〈0.01）.LC group a Class A,B,C level with the severity of liver damage increased,ADA and HCY test results gradually increased,RBP testing results gradually decreased,the difference was statistically significant or highly statistically significant（P〈0.05 or P〈0.01）.Grade A in the three indicators of the positive testing rate of single and joint testing were higher than the control group,the positive testing rate of combined testing was higher than the positive testing rate,the difference was statistically significant（P〈0.05）.Conclusion The three biochemical indexes were closely related to the liver cell damage,which can be used as an important indicator of the degree of liver injury,Joint testing can improve the positive detection rate of early diagnosis of LC,and can provide a reliable laboratory basis for the early diagnosis and treatment,clinical efficacy and prognosis of the LC.
作者
李祥坤
LI Xiang-kun.(The Clinical Laboratory, Central Hospital of Suining , Suining 629000,Chin)
出处
《中国实验诊断学》
2016年第10期1673-1675,共3页
Chinese Journal of Laboratory Diagnosis
