摘要
目的研究缺血修饰白蛋白(IMA)、高敏C反应蛋白(hs-CRP)、氨基末端B型利钠肽前体(NT-proBNP)及可溶性CD40配体(sCD40L)对急性冠脉综合征早期诊断价值。方法分析2013年1月-2014年6月我院收治的47例急性冠脉综合征患者的临床资料(观察组),同时选取42例健康人作为对照组。结果观察组患者血清中IMA水平显著低于对照组,差异具有统计学意义(P<0.05);hs-CRP、NT-proBNP及sCD40L水平明显高于对照组,差异具有统计学意义(P<0.05);不同病理分型ACS患者IMA、hs-CRP、NT-proBNP及sCD40L水平差异有统计学意义(P<0.05);。IMA、hs-CRP、NT-proBNP及sCD40L水平对ACS诊断价值ROC曲线显示,当NT-proBNP截点值为748.7ng/L时对ACS诊断的敏感性为91.67%,特异性为90.48%,诊断价值优于IMA、hs-CRP及sCD40L。结论IMA、hs-CRP、NT-proBNP及sCD40L对于ACS具有一定的早期诊断价值,其中NT-proBNP在ACS诊断上具有较高的敏感性和特异性,可作为ACS诊断的首选指标。
Objective Toinvestigatethe diagnosis value research on early acute coronary syndrome of IMA,hs-CRP, NT-proBNP and sCD40L. Methods Analyzing the clinical data of 47 patients with acute coronary syndrome in our hos- pital from January 2013 to June 2014, and be selected as observation group, 42 cases healthy people were selected as control group. Results IMA levels in observation groups was significantly lower than the control group,the difference is statistically significant（P〈20.05）, the hs-CRP, the NT-proBNP and sCD40Llevels in Observation group are signifi- cantly higher than the control group, the difference have statistically significance（P〈20. 05）;There were significant differences in the levels of IMA,hs-CRP, NT-proBNP and sCD40L between different pathological types of ACS patients （P〈0.05） ;ROC curve shows that ,when the cut-off value of NT-proBNP is 748.7 ng/L,diagnostic sensitivity of ACS is 91.67%,specificity is 90.48% ,the diagnostic value is better than IMA,hs- CRP,and sCD40L. Conclusion IMA,hs- CRP, NT-proBNP and sCD40L has certain diagnostic value for early diagnosis of ACS , the NT-proBNP has higher sensitivity and specificity in diagnosis of ACS,and it can be used as the first diagnosis indicators for diagnosis of ACS.
作者
杨雯婷
YANG Wen- ring.(Department of Cardiology, 163 Hospital of PLA , Changsha 410003 ,China)
出处
《中国实验诊断学》
2016年第12期2034-2037,共4页
Chinese Journal of Laboratory Diagnosis
