摘要
目的:观察自拟补肾活血煎剂联合雌孕激素序贯疗法对宫腔粘连术后子宫内膜影响的临床疗效。方法:选择我院自2013年1月至2014年12月收治的120例宫腔粘连(IUA)患者,随机分为治疗组和对照组各60例,治疗组给予自拟补肾活血煎剂联合雌孕激素序贯疗法治疗,对照组给予雌孕激素序贯疗法治疗,均连续治疗3个月经周期,随访1年。结果:治疗3个月经周期后,对照组和治疗组对IUA患者月经情况改善的总有效率分别为61.82%和85.19%,差异有统计学意义(P<0.05);与对照组相比,自拟补肾活血煎剂联合雌孕激素序贯疗法能显著升高临床症状评分(P<0.05),显著升高患者中医证候变化的总有效率(P<0.05),并能显著降低宫腔粘连程度评分(P<0.05);两组治疗后子宫内膜厚度均较疗前增加,子宫动脉血流阻力指数(RI)及子宫动脉血流搏动指数(PI)较疗前下降,但组间比较无统计学差异(P>0.05);随访1年,两组随机妊娠率分别为9.09%和18.51%差异显著(P<0.05);且在治疗期间无不良反应发生。结论:补肾活血煎剂联合雌孕激素序贯疗法可明显增加患者的月经量并且改善其中医证候,疗效优于单用雌孕激素序贯疗法。治疗后两组患者子宫内膜厚度均较疗前增加,子宫动脉血流阻力指数及子宫动脉血流搏动指数均较疗前下降,可能与其改善子宫血流灌注量、促进子宫内膜修复有关。
Objective： To investigate the clinical efficacy of using Self-made Bushen Huoxue Decoction combined with estrogen-progesterone sequential therapy in the treatment of intrauterine adhesions（ IUA）. Methods： 120 cases of IUA patients came from patients admitted by our hospital during the time from January 2013 to December 2014. These patients were randomly divided into two groups： treatment group and controlled group,60 cases in each group. The people in the treatment group were given Bushen Huoxue Decoction combined with estrogen- progesterone sequential therapy,simultaneously,the ones in the controlled group were given estrogen and progesterone sequential therapy,both treatment last for three menstrual cycles,then followed up for1 year. Results： After treatment of three menstrual cycles,the total effective rate of the treatment group and the controlled group on the menstrual volume,one menstrual period and color quality were 85. 19% and 61. 82% respectively,with statistically significant difference（ P〈0. 05）. Compared with the controlled group,the improvement of the TCM syndromes of the treatment group was also better than the controlled group（ P〈0. 05）,the intrauterine adhesions severity score was remarkably reduced（ P〈0. 05）. The endometrial tihickness of two groups of patients were all increased than before,the uterine artery blood flow RI level and PI level were all lower than before,but there were no significant differences between the two groups（ P〉0. 05）. After one year of follow-up,pregnancy rates of the two groups were 9. 09% and 18. 51%,it was significant difference（ P〈0. 05）. And no adverse reaction was shown during the treatment. Conclusion： TCM therapy of Bushen Huoxue Decoction combined with estrogen-progesterone sequential therapy can significantly improve the menstruation and TCM syndromes,and the effect is better than estrogen-progesterone sequential therapy. After treatments the endometrial thickness of the two groups of patients were all increased than before,the uterine artery blood flow RI level and PI level were all lower than before,possibly by improving uterine perfusion and promoting endometrial repair.
出处
《四川中医》
2016年第12期126-129,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
宫腔粘连
补肾活血煎剂
雌孕激素序贯疗法
子宫内膜
临床观察
Intrauterine adhesions
Bushen Huoxue Decoction
Estrogen-progesterone sequential therapy
Endometrium
Clinical observation
