摘要
目的:探讨最大颈动脉内膜中层厚度(max-cIMT)与脂蛋白相关磷脂酶A2(Lp-PLA2)活性对冠心病的预测作用。方法:比较冠脉正常组(73例)、稳定性心绞痛组(35例)和急性冠脉综合征(ACS)组(43例)3组患者的基本临床资料、max-cIMT及Lp-PLA2血浆浓度的差异。结果:(1)3组患者间年龄、性别、高血压、他汀服用史等差异无统计学意义,吸烟、糖尿病史及高密度脂蛋白胆固醇(HDL-C)水平差异有统计学意义(P<0.05);(2)max-cIMT与Lp-PLA2活性冠脉正常组最低,ACS组最高(P<0.01);(3)均衡其它危险因素,Lp-PLA2活性、max-cIMT及HDL-C水平与冠心病独立相关(P<0.05);(4)max-cIMT与Lp-PLA2活性诊断冠心病的受试者工作特征曲线之曲线下面积(AUC)分别为0.748与0.85(P<0.01)。结论:max-cIMT及Lp-PIA2活性与冠心病的发生均相关,均可以作为冠心病的危险预测因子。
Objective： To investigate the predictive value of maximum carotid intima-media thickness （max- cIMT） and lipoprotein- associated phospholipase A2 （ Lp- PLA2） in the diagnosis of coronary heart disease （CHD）. Methods： One hundred and fifty-one cases of suspected CHD were divided into three groups：non-CHD group（ n = 73 ）, stable angina pectoris group （ n = 35 ） and acute coronary syndrome （ ACS ） group （ n = 43 ）. The differences of basic clinical data, the max-cIMT and Lp-PLA2 in the three groups were detected and compared. Results： （ 1 ） The age, gender, hypertension control, history of taking statins, LVEF and the levels of TC, TG, LDL- C, apo- A and apo-B had no statistical difference in the three groups, while there were statistically significant difference in patients with history of smoking and diabetes, and the value of HDL- C （ P 〈 0.05 ）. （ 2 ） There were significant differences in max-cIMT and Lp- PLA2 （ P 〈 0.01 ）. （ 3 ） After adjusting other risk factors, Lp-PLA2, max- c IMT and HDL- C were independently associated with coronary heart disease （ P 〈 0.05 ）. （4） The area under the ROC curve （AUC） of the max- cIMT and Lp- PLA2 in the diagnosis of CHD was 0. 748,0.85 （ P 〈 0.01 ）. Conclusion： The maximum cIMT and Lp-PLA2 are correlated with the occurrence of CHD ,both of which can be used as predictors of CHD risk factors.
出处
《现代医学》
2016年第11期1487-1492,共6页
Modern Medical Journal
基金
南京军区医药卫生科研基金资助项目(14ZD22)
关键词
颈动脉内膜中层厚度
冠心病
脂蛋白相关磷脂酶A2
急性冠状动脉综合征
carotid intima- media thickness
coronary heart disease
lipoprotein- associated phospholipase A2
acute coronary syndrome
