摘要
目的:探讨立体定向放射治疗(SRT)肝脏恶性肿瘤的临床疗效。方法:采用立体定向γ-射线体部治疗系统治疗112例肝脏恶性肿瘤患者,根据肿瘤的位置、临床靶体积、病人的身体状况与治疗目的,制定放射治疗计划及调整剂量分布。等剂量曲线50%～90%,周边照射剂量2500～4800 cGY,中位剂量3362.6cGy,分割处方剂量300～800cGy,重复治疗4～12次,隔日治疗。结果:治疗结束后3～13个月,肝区疼痛症状缓解率为92.3％,生存质量明显提高。83例复查CT或MR,肿瘤消失13例(15.7%),缩小44例(53.0%),无变化18例(21.9%),增大8例(96.%),有效率为90.4%。肿瘤较小与单发病灶者冶疗效果较好,曾在SRT前接受介入治疗者治疗效果优于未接受介入治疗者。结论:SRT肝脏恶性肿瘤使肿瘤局部得到准确的高剂量照射,周围正常组织损伤较小,近期治疗效果较为理想,为肝脏恶性肿瘤患者提供了一种新的治疗方法。
Purpose: To research the clinical therapeutic effectiveness of stereotactic radiotherapy (SRT) in the patients with hepatic malignant tumor. Methods: 112 patients with hepatic malignant tumor were treated with stereotactic 7-ray body therapentic system. Radiotherapeutic plan and dosage distribution were set on the basis of the tumor position, clinical target volume, patient health condition. The isodosage curve was 50% -90%. The fractional doses was 300 - 800 cGy. The therapy had been repeated for 4-12 times, every two days one time. Results: After the therapy 3 to 13 months the remission rate of hepatic region pain is 92. 3%. The survival quality of patients was improved significant. 83 patients received CT or MR test. The carcinoma disappeared in 13 cases(15. 7% ), shrank in 44 cases(53. 0% ) , no varied in 18 cases(21. 9% ) , and augmented in 8 cases(9. 6% ). The therapeutic efficiency rate is 90. 4% . The therapeutic effectiveness in the patients with minor and solitary was better. And who received local chemotherapy prior to SRT was better also. Conclusion: The therapeutic effectiveness of short term for the patients with hepatic malignant tumor with SRT has accurate localization, high dose irradiation, and mild side reaction. The results are satisfactory.
出处
《临床消化病杂志》
2002年第4期147-149,共3页
Chinese Journal of Clinical Gastroenterology
