摘要
目的分析直肠癌MRI非形态学表征(血流动力学、功能学)与Her-2表达水平的相关性。方法回顾性分析56例经手术病理证实的直肠癌患者,术前行盆腔常规MRI、直肠DWI及增强扫描,分别记录病灶时间-信号强度曲线、早期强化率,测量ADC值,应用t检验、χ~2检验及非参数Spearman秩相关与Her-2表达水平进行相关分析。结果直肠癌时间-信号强度曲线、早期强化率与Her-2表达无明确相关。ADC值与Her-2表达程度呈负相关(r=-0421,P=0.001<0.05)。非参数多个样本Kruaskal-Wallis检验法分析显示:Her-2表达程度不同组间病灶ADC值间差异具有统计学意义(F=6.010,P=0.003<0.05)。应用ROC曲线分析显示,判断Her-2表达的最佳ADC值诊断界值为1.160×10^(-3)mm^2/s。结论直肠癌血流动力学指标尚不足以反映Her-2表达程度,而ADC值与Her-2表达程度呈负相关,ADC值能在一定程度上间接评价肿瘤增殖及预后。
Objective To explore the correlations of MRI non-morphological features（ hemodynamic performance and function characteristics） and Her-2 Expression of rectal cancer. Methods Fifty-six patients diagnosed with rectal cancers by pathologic examination were reviewed,and analysis of the MRI non-morphological features and the Her-2 expression was done to explore the pathological changes of the time-signal intensity curve,early intensive rate and ADC values,using t-test and chi-square test and Spearman rank correlation analysis with the correlation of Her-2 expression. Results The timesignal intensity curve of colorectal cancer,early intensive rate had no correlation with Her-2 expression; ADC values had negative correlation with Her-2 expression（ r =- 0421,P = 0. 001〈0. 05）,ADC values differences between the groups of Her-2 expression was statistically significant（ F = 6. 010,P = 0. 003〈0. 05）,the best threshold of ADC value to conclude Her-2 expression was 1. 160 × 10^（- 3） mm^2/ s by ROC curve. Conclusion Her-2 expression had no correlation with MRI hemodynamic performance indicators; it had negative correlation with ADC values. ADC values can evaluate indirectly tumor proliferation and prognosis of rectal cancer to some extent.
出处
《临床放射学杂志》
CSCD
北大核心
2016年第12期1843-1847,共5页
Journal of Clinical Radiology
基金
广西医疗卫生适宜技术研究与开发课题(编号:S201417-06)
广西壮族自治区卫生与计划生育委员会自筹经费科研课题(编号:Z2015616)资助
关键词
直肠癌
磁共振成像
HER-2
Rectal cancer
Magnetic resonance imaging
Her-2
