摘要
目的观察胃铋镁联合埃索美拉唑、阿莫西林、克拉霉素治疗Hp相关系消化性溃疡的临床效果。方法选择2014年6月~2016年5月百色市人民医院收治的172例消化性溃疡合并Hp感染的患者,随机分为三组:标准三联组60例、胃铋镁四联组56例、胶体果胶铋四联组56例。标准三联组给予埃索美拉唑、克拉霉素、阿莫西林口服10 d,然后PPI继续口服28 d;胃铋镁四联组在标准三联组的基础上,给予胃铋镁颗粒口服10 d;胶体果胶铋四联组在标准三联组基础上,给予胶体果胶铋胶囊口服10 d。观察患者疼痛症状缓解、溃疡愈合、Hp根除、药物不良反应情况。结果胃铋镁四联组Hp根除率(94.6%,53/56)、疼痛症状缓解率(85.7%,48/56)、溃疡愈合有效率(89.3%,50/56)均显著优于标准三联组(68.3%,41/60;43.3%,26/60;70.0%,42/60),其不良反应发生率(14.3,8/56)显著低于标准三联组(31.7%,19/60),差异均有统计学意义(前两项P<0.05,后两项P<0.01)。胶体果胶铋四联组上述四项结果与标准三联组比较,差异均无统计学意义(P>0.05)。胃铋镁四联组疼痛症状缓解率优于胶体果胶铋四联组,差异有统计学意义(P<0.01)。结论胃铋镁四联疗法治疗Hp阳性消化性溃疡更能快速缓解患者疼痛症状,对Hp根除、溃疡愈合效果显著,且未增加不良反应,在治疗消化性溃疡上具有一定的优势和较好的安全性。
Objective To observe clinical effect compound Bismuth Magnesium Granules combined with Esomeprazole,Amoxicillin and Clarithromycin in the treatment of Hp-related peptic ulcer.Methods 172 patients with Hp infection-positive peptic ulcer disease in People′s Hospital of Baise City from June 2014 to May 2016 were randomly divided into 3 groups,60 cases in standard triple therapy group,56 cases in compound Bismuth Magnesium quadruple therapy group,56 cases in colloidal bismuth pectin quadruple therapy group.Patients in the standard triple therapy group were given Esomeprazole,Clarithromycin,Amoxicillin for 10 days,and then with oral Esomeprazole for another 28 days.The other two groups was added compound Bismuth Magnesium Granules and colloidal bismuth pectin for 10 days on the basis of the standard triple therapy treatment respectively.The remission of pain symptoms,ulcer healing,Hp eradication rates,ADR of three groups were observed.Results Hp eradication rate（94.6%,53/56）,remission rate of pain symptoms（85.7%,48/56）,ulcer healing rate（89.3%,50/56） of compound Bismuth Magnesium quadruple therapy group was significantly better than that of standard triple therapy group（68.3%,41/60;43.3%,26/60;70.0% 42/60）,ADR rate（14.3,8/56）was significantly lower than（31.7%,19/60） of standard triple therapy group（the former two items were P〈0.05,the latter two ite ms were P〈0.01）.There was no statistical significance between four items results of colloidal bismuth pectin quadruple therapy group（83.9%,47/56;58.9%,33/56;83.9%,47/56;19.6%,11/56） and standard triple therapy group（P〉0.05）,while remission rate of pain symptoms had statistical significance between compound Bismuth Magnesium quadruple therapy group and colloidal bismuth pectin quadruple therapy group（P〈0.01）.Conclusion Compound Bismuth Magnesium quadruple therapy in the treatment of Hp-related peptic ulcer has better effect in remission of pain symptoms,and significant effects on ulcer healing and Hp eradication.What′s more,it does not add ADR.So it has a certain advantage and a better safety in the treatment of peptic ulcer.
出处
《中国当代医药》
2017年第1期46-48,共3页
China Modern Medicine
关键词
消化性溃疡
HP根除
胃铋镁颗粒
四联疗法
胶体果胶铋
Peptic ulcer
Hp eradication
Compound Bismuth Magnesium Granules
Quadruple therapy
Colloidal bismuth pectin
