摘要
目的:探讨血液净化治疗的重症患者血流感染的发生率,同时了解其血流感染的病原学分布情况以及耐药性特点,为临床合理用药提供参考依据。方法:选取2014年8月-2016年7月本院内科ICU行血液净化治疗的患者218例,对明确新发血流感染患者的致感染因素进行分析,同时分析其病原菌分布情况及耐药性特点。结果:218例患者发生新发血流感染者35例,占比16.06%,第二观察年限内发生率较第一观察年限有明显下降(P<0.05)。第一年观察年限分离出的致病菌构成以真菌及G-杆菌为主,第二观察年限分离出的致病菌构成以G+球菌及真菌为主。第一观察年限耐药率为38.10%(8/21),第二观察年限耐药率为57.14%(8/14)。结论:血液净化治疗的重症患者血流感染的发生率较高,病情病原菌中真菌属、G-杆菌、G+球菌分别为34.3%、31.4%、34.3%,G-杆菌耐药情况较为严重,而耐甲氧西林葡萄球菌有增多趋势,抗菌药物选择应同时兼顾G-菌和G+菌。
Objective： To investigate the incidence of bloodstream infection in patients with severe blood purification treatment, and to understand the pathogenic distribution and drug resistance characteristics of blood flow infection, so as to provide reference for clinical rational drug use.Method： A total of 218 patients＇ blood in our hospital ICU were selected from August 2014 to July 2016, the clear new cases caused by infection factors analysis of bloodstream infection, the pathogen distribution and drug resistance were analyzed.Result： The incidence of new bloodstream infection in 218 patients was 35 cases, accounting for 16.06%, the incidence of the second observation period was significantly lower than the first observation period （ P〈0.05 ） .The pathogenic bacteria isolated from the first obseivation period were mainly fungi and G- bacilli, the pathogenic bacteria isolated from the second observation period were mainly G＋ cocci and fungi.The first observation period resistance rate was 38.10% （ 8/21 ）, the second observation period resistance rate was 57.14% （ 8/14 ） .Conclusion： The blood purification treatment of severe blood flow in patients with a higher incidence of infection, fungi, Bacillus G- and G＋ strains were respectively 34.3%, 31.4% and 34.3% in the condition of pathogenic bacteria, G- bacteria drug resistance is serious, and methicillin-resistant Staphylococcus aureus is increasing, the selection of antimicrobial agents should take into account both the G- and G＋ strains.
出处
《中国医学创新》
CAS
2016年第36期108-111,共4页
Medical Innovation of China
关键词
血流感染
血液净化治疗
菌群分布
耐药性
Bloodstream infection
Blood purification therapy
Bacterial distribution
Drugresistance
