摘要
目的:系统评价艾条灸灸量累积时间参数(间隔时间和疗程)对原发性痛经(PD)临床疗效的影响。方法:计算机检索CENTRAL、MEDLINE、EMBASE、AMED、CINAHL、Web of Science、CBM、CNKI、VIP和Wangfang Data,检索时间均从建库至2015年12月,搜集国内外有关艾条灸治疗PD的临床随机对照试验(RCT)。由2名研究者按照纳入排除标准独立筛选文献及提取数据,参照Cochrane Handbook进行偏倚风险的评估,采用Rev Man5.2软件进行Meta分析。结果:纳入12项RCT,共586例患者。Meta分析结果显示:艾条灸持续治疗3个疗程(3个月经周期)能提高PD患者的总有效率[RR=1.16,95%CI(1.06~1.27),P=0.001],降低血PGF2α水平[MD=-4.65,95%CI(-8.42^-0.88)],缓解疼痛的效果与对照组非艾条灸相当[MD=0.14,95%CI(-0.11~0.39)];治疗3个疗程后,不同累积治疗量(P=0.09)、不同间隔时间之间相比(P=0.1),对疗效影响的差异均无统计学意义;累积治疗量相同时,施灸每日1次和隔日1次相比,对疗效影响的差异无统计学意义(P=0.64)。结论:现有临床证据表明,3个月经周期可作为艾灸治疗PD产生临床疗效的常规疗程;每日1次和隔日1次的频度差异不明显,可根据患者的具体情况灵活安排就诊时间,从卫生经济学角度,可选择隔日1次的治疗方案。受纳入研究质量和数量的限制,上述结论需更多高质量的研究予以验证。
Objective： To systematically evaluate efficacy of different time parameters of moxibustion on primary dysmenorrhea. Methods： CENTRAL, MEDL1NE, EMBASE, AMED, CINAHL, Web of Science, CBM, CNKI, VIP and Wanfang Data were searched, to collect some studies on treating PD by moxibustion. RCTS were independently selected by two researchers according to the inclusion and exclusion criteria, and assessed quality of studies according to the Cochrane Handbook. A Meta-analysis was performed by RevMan5.2 software. Results： 12 studies were selected, involving 586 cases of PD. In 3 menstrual cycles, moxibustion can improve the total efficiency [RR= I. 16, 95%CI （1.06-1.27）, P=0.001], reduce the level of PGF2~ [MD=-4.65, 95%CI （-8.42- -0.88）], relieve the pain in the control group [MD=0.14, 95%CI （-0.11-0.39）]. With the different therapeutic dose （P=-0.09）, interval time （P=-0.1）; the efficiency shows a statistically significant different （P=-0.64）. Conclusion： 3 menstrual cycles can be used as a routine treatment of PD. We can flexible arrangement of visiting hours. Due to the limitations of the quality of studies, the results should be cautious application.
出处
《中医临床研究》
2016年第34期14-20,共7页
Clinical Journal Of Chinese Medicine
关键词
艾灸
原发性痛经
间隔时间
疗程
META分析
Moxibustion
Primary dysmenorrhea
Interval time
Course
A Meta-analysis
