摘要
手足癣是皮肤科较常见的浅部皮肤真菌感染性疾病之一,临床上分为水疱鳞屑型、角化过度型和浸渍糜烂型,具有传染性、复发性的特点,其致病真菌主要为红色毛癣菌、白色念珠菌等。手足癣在我国发病率较高,而现阶段对手足癣的关注度较其他常见皮肤科疾病相对较低、研究工作也较少。目前常用的临床治疗手足癣的方法主要分为西医治疗、中医治疗及中西医结合治疗。西医治疗常选用抗真菌药物,主要包括外用药和口服药,但部分外用药治疗过程中会出现耐药性且停药后易复发,部分口服药物治疗过程中还会出现明显的不良反应,如肝毒性等,具有一定的局限性。中医中药外治法治疗手足癣的历史悠久,疗效较佳且副作用小,有较好的优势。现系统查阅并收集了近10年中医临床治疗手足癣的相关文献,根据中医病因、病机确立了"清热燥湿、杀虫止痒"的基本治则,同时对常用中药制剂方面进行了归纳总结;通过中医方解与现代中药药理研究分析了相关单味中药的功效与药理作用,发掘与总结中医中药治疗特色的临床实用价值。对既往与近期研究新进展情况进行了综述,同时从制剂工艺与质控标准、药效与毒理、临床疗效评价三个方面分析了目前存在的不足之处,以期为更好地提高中医治疗手足癣提供更多的思考与方法。
Tinea manuum and pedis is a type of common fungal infectious disease with recurrence in dermatology department of hospital. Clinically,they can be classified into blister-scale type,keratotic type and impregnated erosive type. The main pathogenic fungi include Trichophyton rubrum and Candida albicans. Although tinea manuum and pedis has a high incidence rate in China,it has not currently attracted enough attention compared with other dermatological diseases,thus been included into fewer researches. Now,three commonly used therapies include western medicine,traditional Chinese medicine（ TCM） and integrated western medicine and TCM. Western medicine therapy usually involves anti-fungal medicines for external use or oral administration;however,some of the medicines for external use can cause drug resistance,recurrence after discontinuance and adverse reactions,like hepatotoxicity. Compared with western medicines,TCM,with a long application history,are effective with limited side effects. The literatures about the treatment for tinea manuum and pedis with TCM in the past 10 years are systematically searched and collected. Based on the disease etiology and pathogenesis,the basic principles of ‘removing heat,eliminating dampness,sterilizing and relieve itching＇have been established for treating tinea manuum and pedis,and the formulations are summarized. The efficacy and pharmacological effect of single herb are analyzed through an analysis on formulation components and pharmacological research for modern Chinese medicines. Afterwards,the clinical values of TCM are further elaborated. Through the analysis of previous and recent researches on the treatment of tinea manuum and pedis by TCM,limitations are investigated in aspects of preparation process and quality control standard,pharmacological effect and toxicology,and evaluation of clinical efficacy,in the expectation of providing more ideas and methods for improving TCM therapies for tinea manuum and pedis.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第2期207-212,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
上海市科委科研计划项目(15401972400)
关键词
手足癣
中医临床治疗
方解分析
药理作用
tinea manuum and pedis
clinical treatment with traditional Chinese medicine
formulation analysis
pharmacological effect
