摘要
伴随着我国医药卫生事业的蓬勃发展和医药科技水平的快速提升,传统中医药的现代应用吸引了全球范围内的瞩目,其良好的治疗效果获得了国内外的广泛认可。然而,在实际临床应用中,中药不良反应报道却也在逐渐增多,特别是一些传统意义上被认为无毒的中药,在使用过程中出现了新的不良反应或毒性反应,致使中药的安全性问题更加备受关注。目前,在中医药临床用药安全研究方面,医务人员及医药研究工作者将大部分的注意力集中在具有已知毒性的药物上,基本能够做到准确、有效地把控,而对那些已经出现不良反应报道,但尚未引起重视的潜在毒性中药却关注甚少,导致因忽视潜在毒性药物而形成的用药安全漏洞,长此下去势必造成用药安全的重大隐患。因此,本文针对近年来发现的具有潜在毒性的中药及其毒性主要表现进行了系统总结,并从个体体质差异、药材基原、药用部位、药材产地、炮制方法、制剂工艺、药物用量、用药疗程的角度,对这类中药潜在毒性产生的原因进行全面分析,从而引起对潜在毒性药物应用安全的普遍重视,为进行药物毒性深入的科学研究提供有力依据,为指导临床安全、合理地使用中药提供可靠借鉴,有助于在充分发挥中药临床应用有效性的基础上,进一步提高中药使用的安全性保障水平。
With the vigorous development of medical hygienic cause and the rapid advance of medical technology in China,modern application of traditional Chinese medicine（ TCM） has attracted attention from the world,and its good therapeutic effect has widely recognized at home and abroad. However,in practical clinical application,TCM＇s adverse reaction reports have gradually increased. Especially,some medicines that were known as non-toxic showed new adverse reactions or toxic reaction during administration; Accordingly,the safety of TCM became a concern. At present,medical workers and pharmaceutical researchers pay more attention to the known toxic herbs in clinical medicines,and could accurately and effectively control them; However,they pay less attention to potentially toxic herbs that have showed adverse reactions but been given no attention. This caused a drug security hole and would lead to major hidden troubles. Therefore,in this paper,a systematic summary was made on traditional Chinese medicines with potential toxicity discovered in recent years,and a comprehensive analysis was conducted for their causes of potential toxicity from perspectives of individual constitution differences,origin,medicinal parts,producing area,processing methods,preparation process,drug dose and course of treatment,with the aim to raise universal attention to application safety of TCM with potential toxicity,provide sufficient basis for in-depth scientific researches for drug toxicity and reference for safe and rational clinical application of TCM,and further improve the safety of TCM in addition to effective clinical application.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第2期227-234,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81274181
81374056)
关键词
中药
潜在毒性
安全用药
不良反应
traditional Chinese medicine（TCM）
potential toxicity
safe medication
adverse reaction
