摘要
化学战和化学恐怖是当今人类生存、国家安全所面临的重大威胁之一。以特异性抗毒药物为核心的有效医学对抗措施是应对各种化学威胁的关键。近10余年来,世界范围内地区冲突和恐怖活动中化学攻击事件的不断发生,再加上有意或无意的化学事故带来的现实或潜在化学威胁,使得各国重新加强了对抗毒药物及其相关研究的重视和投入,取得了明显进展。本文首先以美国"化学威胁对抗措施(CounterACT)"研究计划为例,介绍近年化学威胁医学对抗措施研究的主要动向,进而以几种代表性化学毒剂(毒物)损伤防治药物研究为例,介绍近来抗毒药物研究的现状和主要进展。
Chemical warfare agents and chemical terrorism agents have been identified as one of the major threats to human survival and national security currently. The key to dealing with these threats is the effective medical countermeasures of which specific antidotes take center stage. In the past decade,real or potential chemical threats which has sparked regional conflicts,terrorist activities or chemical accidents intentionally or unintentionally have increased the investment in antidotes research and development worldwide. Here,we introduced the research status on medical countermeasures against chemical threat by giving an overview of the United States ″Countermeasures Against Chemical Threats（CounterACT）Program″,and then the recent research progress in antidotes against nerve agents,sulfur mustard and cyanide toxicities were reviewed.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2016年第12期1411-1418,共8页
Chinese Journal of Pharmacology and Toxicology
