摘要
目的:了解引起药物疹的药物种类、皮疹类型、给药方式,为临床上避免药品不良反应(ADRs)提供参考。方法:对解放军第三O九医院皮肤科自2014年6月-2016年5月处置的药物疹病人进行统计并分类分析。结果:共记录223例药物疹病例资料,与用药肯定有关16例(7.17%),很可能有关117例(52.47%),可能有关90例(40.36%)。共涉及85个品规药物,以抗菌药物为主(82例,36.77%)。给药方式以口服为主,皮疹类型以麻疹样红斑为主,重症药物疹21例,占9.42%。结论:临床工作中要了解病人的药物过敏史,尽量减少药物种类和规范使用剂量,提高用药合理性,以减少药物疹发生率。
Objective： To investigate the drug type that might induce drug eruption, types of eruption and routes of medication, so as to provide evidence to avoid adverse drug reactions （ADRs）. Methods： Medical data of the drug eruption patients admitted into the Department of Dermatology, No. 309 Hospital of the PLA from June 2014 to May 2016 were registered, classified and analyzed. Results： There were totally 223 cases of drug eruption, of which 16 were positively sure cases （accounting for 7.17%）, 117 were every likely cases （accounting for 52.47%） and 90 were probable cases （accounting for 40.36~）. A total of 85 types of drugs were involved, with antimicrobial agents as the chief source （82 cases, accounting for 36.77%）. The routes of medication were mainly oral. The rash type was mainly measles-like erythema, and there were 21 cases of severe drug eruption, accounting for 9.42 % of the total eruption. Conclusion： Clinical medical personnel should know allergic history of the patients, reduce drug types and standardize drug dosages, so as to improve the rationality of drug usage and reduce incidence of drug eruption.
出处
《药学服务与研究》
CAS
2016年第6期478-480,共3页
Pharmaceutical Care and Research
关键词
药疹
合理用药
药物副反应报告系统
drug eruption
rational use o{ drugs
adverse drug reaction reporting system
