摘要
目的:探讨保妇康栓联合壳聚糖抗菌膜对宫颈上皮内瘤变(CIN)患者行宫颈锥切术后疗效及相关指标的影响。方法:200例拟行宫颈锥切术的CIN患者随机分为对照组(100例)和观察组(100例)。两组患者均于月经干净2~7 d后行宫颈锥切术;术后,对照组患者给予壳聚糖抗菌膜1片,以无菌操作杆推入阴道并贴敷于创面,以纱块进行填塞,每2 d更换1次;观察组患者在对照组治疗的基础上给予保妇康栓1粒,阴道置入,每日1次。两组疗程均为2周。观察两组患者的临床疗效,创面愈合时间、阴道排液时间,治疗前后的炎症因子[白细胞介素(IL)-4、IL-10、肿瘤坏死因子(TNF)-α]水平,记录术后并发症及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,创面愈合时间和阴道排液时间均显著短于对照组,术后并发症发生率显著低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者炎症因子水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:宫颈锥切术后,保妇康栓联合壳聚糖抗菌膜治疗CIN的疗效显著,可有效提高术后患者创面愈合效果,降低炎症反应水平及术后并发症发生率,且不增加不良反应的发生。
OBJECTIVE： To explore the effects of Baofukang suppository combined with Chitosan antibacterial film on the effi- cacy and related indicators in patients with cervical intraepithelial neoplasia （CIN） after cervical conization. METHODS： 200 CIN patients undertaking cervical conization were randomly divided into control group （100 cases） and observation group （100 cases）. All patients took cervical conization after 2-7 d of menstruation; control group was given Chitosan antibacterial film 1 tablet, push- ing into the vagina and depositing in the wound by aseptic lever, then stuffing by yam blocks, replaced once every 2 d; observa- tion group was additionally given Baofukang suppository 1 granule, placing in the vagina, once a day. They were treated for 2 weeks. Clinical efficacy, wound healing time, vaginal discharge time, inflammatory cytokine levels [interleukin （IL）-4, IL-10, tu- mor necrosis factor （TNF） -α] before and after treatment were observed, and the postoperative complications and incidence of ad- verse reactions were recorded. RESULTS： The total effective rate in observation group was significantly higher than control group, wound healing time and vaginal discharge time were significantly shorter than control group, the incidence of postoperative compli- cations was significantly lower than control group, with statistical significances （P〈0.05）. After treatment, the inflammatory cyto- kine levels in 2 groups were significantly lower than before, and observation group was lower than control group, with statistical significances （P〈0.05）. And there was no significant difference in the incidence of adverse reactions between 2 groups（P〉0.05）. CONCLUSIONS： After cervical conization, Baofukang suppository combined with Chitosan antibacterial film shows obvious effica- cy in the treatment of CIN, it can effectively improve postoperative wound healing effect, reduce the levels of inflammatory reac- tions and the incidence of postoperative complications, and does not increase the incidence of adverse reactions.
出处
《中国药房》
CAS
北大核心
2017年第3期338-341,共4页
China Pharmacy
关键词
保妇康栓
壳聚糖抗菌膜
宫颈上皮内瘤变
宫颈锥切术
疗效
安全性
Baofukang suppository
Chitosan antibacterial film
Cervical intraepithelial neoplasia
Cervical conization
Efficacy
Safety
