摘要
微小RNA主要通过其种子序列识别靶基因,在转录后水平调控基因表达,参与多种生理和病理过程。肾小球系膜细胞是肾小球最主要的细胞之一,各种致病因子作用时,系膜细胞明显增殖、功能紊乱,分泌大量细胞因子,引起细胞外基质合成增多,最终导致肾小球硬化、肾脏纤维化。已有报道表明多种微小RNA参与系膜细胞损伤,在肾脏纤维化过程中发挥重要作用,可能是肾脏病早期干预治疗的潜在靶点。
MicroRNA could participate in a variety of physiological and pathological processes via identifying the target genes by their seed sequences and regulating gene expression at post-transcriptional level. Glomerular mesangial cell is one of the most chief cells of the glomerulus and plays an important role in the renal fi brosis. The mesangial cellular proliferation and dysfunction may appear once attacked by pathogenic factors. Then, the extracellular matrix increases in the stimulation of inflammatory cytokines, eventually, resulting in glo- merular sclerosis and renal fibrosis. Reports have shown that series of microRNA could take part in the process of injury of mesangial cells and lead to renal fibrosis. MicroRNA could be a potential therapeutic target for early chronic kidney diseases.
出处
《国际儿科学杂志》
2016年第12期928-931,共4页
International Journal of Pediatrics