摘要
对证和配伍是控制有毒中药毒性的两个必要措施。中药成分的复杂性是限制控毒研究深入开展的重要因素。在系统生物学指导下,探索组分配伍干预对证动物模型的蛋白质表达谱和代谢物谱,明确与毒性减低相关的标志物;采用分子网络分析技术整合多组学信息,找到调控减毒的关键分子和途径,并以分子生物学方法验证,从而揭示在对证机体中组分配伍控毒的分子机制。
Being exposed to specific syndromes of Chinese medicine （CM） and being compatible with other Chinese herbs are two necessary methods for controlling the toxicity of toxic Chinese herbs. The complexity of Chinese herbal components causes the difficulties in in-depth study of toxicity control. Under the guidance of systems biology, authors studied protein expression profiles and metabolite spec- trums by Chinese herbal compatible components intervening animal model with specific syndrome of CM, thus clarifying corresponding biomarkers relevant to toxicity reducing and control. Authors found out key molecules and pathways for toxicity reducing and control by molecular network technologies using and o- verlaying information integrating. All these mentioned above were finally verified by molecular biologic methods, therefore, revealing the molecular mechanism of toxicity control effects of Chinese herbal compatible components in specific syndromes of CM.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2017年第1期115-118,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(No.81273884)
关键词
有毒中药
对证控毒
组分配伍
toxic Chinese herbs
toxicity-controlling effects in specific syndromes of Chinesemedicine
Chinese herbal compatible components
