摘要
目的观察慢性肾衰竭湿热证患者血清中活性氧(ROS)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平的变化,探讨清肾颗粒(白花蛇舌草、丹参、茵陈等)对氧化应激的干预作用。方法选择70例慢性肾衰竭湿热证患者,随机均分为对照组和治疗组,最终完成60例,治疗组31例,对照组29例,并设正常组20例。治疗组与对照组均给予中药保留灌肠及西医基础治疗,治疗组加服清肾颗粒,疗程均为8周。观察治疗前后24 h尿蛋白定量(U-Pro/24 h)、血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率估算值(e GFR)以及血清中ROS、MDA、SOD水平,并与正常组比较。结果治疗组临床疾病疗效和中医证候疗效总有效率均为83.87%,优于对照组的51.72%和48.28%。治疗后治疗组U-Pro/24 h、Scr、BUN水平显著下降,e GFR水平显著升高,且与对照组相比有明显差异。治疗组和对照组治疗前ROS、MDA水平均显著高于正常组,SOD水平均显著低于正常组;治疗后治疗组ROS、MDA水平均有所降低,SOD水平有所升高,治疗组优于对照组。结论清肾颗粒能改善慢性肾衰竭湿热证患者的临床症状,降低U-Pro/24 h、Scr、BUN,升高e GFR水平,抑制氧化应激,增强抗氧化能力,从而延缓肾纤维化的发展。
AIM To observe the changes of serum ROS,MDA,SOD levels in chronic renal failure（ CRF）patients with damp-heat syndrome and to explore the intervention effect of Qingshen Granules（ Hedyotis diffusae Herba,Salviae miltiorrhizae Radix et Rhizoma,Artemisiae scopariae Herba,etc.） on oxidative stress. METHODS Seventy cases of CRF patients with damp-heat syndrome were randomly and equally divided into control group and treatment group. Sixty cases completed the study,thirty-one cases in the treatment group,twenty-nine cases in the control group. Twenty other cases served as the normal group. The treatment group and the control group were given the basic treatment of western medicine and retention enema of TCM. The treatment group was added Qingshen Granules for eight weeks. The levels of U-Pro /24 h,Scr,BUN,estimated glomerular filtration rate（ e GFR）,serum ROS,MDA and SOD were measured before and after the treatment,and were compared with the normal group. RESULTS Both total effective rates on disease and on traditional Chinese medicine syndrome in the treatment group were 83. 87%,significantly higher than those in the control group（ 51. 72% and 48. 28%）,respectively. The levels of U-Pro /24 h,Scr and BUN were obviously lower in the treatment group after the treatment,and e GFR was obviously higher as compared with those in the control group. Before the treatment,the levels of ROS and MDA in the treatment and control groups were significantly higher than those in the normal group,and the level of SOD was significantly lower; the levels of ROS and MDA were reduced in the treatment group after the treatment,and the level of SOD was increased; these changes in the treatment group were more significant than those in the control group. CONCLUSION Qingshen Granules can ameliorate clinical symptoms in CRF patients with damp-heat syndrome,decrease the levels of U-Pro /24 h,Scr and BUN,increase e GFR level,inhibit oxidative stress,and enhance antioxidant capacity,ultimately delay the development of renal fibrosis.
出处
《中成药》
CAS
CSCD
北大核心
2017年第1期46-50,共5页
Chinese Traditional Patent Medicine
基金
国家自然科学基金项目(81473673
81403372)
安徽省自然科学基金项目(1508085MH198
1308085QH143)
关键词
慢性肾衰竭
湿热证
氧化应激
清肾颗粒
chronic kidney disease
damp-heat syndrome
oxidative stress
Qingshen Granules
