摘要
激发光诱发视网膜色素上皮（RPE）细胞中脂褐素产生的自身荧光（AF）与RPE细胞内脂褐素含量分布有关，反映了RPE及光感受器细胞功能状态。眼底AF（FAF）检查是一种无创的眼底影像检查技术，能够提供其他视网膜影像检查技术无法提供的RPE及光感受器细胞功能信息，为研究不同眼底疾病的发病机制、监测病情进展、判断预后、指导治疗提供帮助。但临床常见眼底疾病因其病变类型、程度以及病程所导致的RPE和光感受器细胞损害不同，FAF表现复杂多变。不同疾病可能表现为相同FAF特征，而同一疾病在发展的不同阶段又有不同的FAF表现。所以，临床常见眼底疾病FAF特征及其意义值得进一步深入观察与探讨。
Autofluorescence is produced by lipofuscin in retinal pigment epithelium （RPE） cells which is induced by exciting light and enables the visualization of lipofuscin changes in the RPE cells, thus showing the function of RPE and photoreceptor cells. Fundus autofluorescence （FAF） imaging is a non-invasive imaging technique providing information of RPE and photoreceptor cells, which is not obtainable with other imaging modalities. The scope of applications includes identification of diseased RPE in retinal diseases, elucidating pathophysiological mechanisms, estimating disease progression and prognosis, guiding treatment protocols. Common fundus diseases have different pathological types, levels and causes, so they can cause various damages of RPE and photoreceptor cells which induce complicated FAF, It is worth further observing and investigating the common retinal diseases＇ FAF characteristics and clinical applications.
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2017年第1期83-86,共4页
Chinese Journal of Ocular Fundus Diseases
关键词
荧光
视网膜疾病诊断
诊断显像
综述
Fluorescence
Retinal diseases/diagnosis
Diagnostic imaging
Review
