摘要
目的采用文献计量学方法分析传统中药益母草的研究现状和在疾病防治中的应用。方法计算机检索CBM、CNKI、Wan Fang Data、EMbase和Ovid(MEDLINE)数据库,搜集益母草相关的研究文献,检索时间均从建库至2016年8月26日。按发表时间、发表杂志、文献主题、益母草剂型等对文献进行筛选和分类,分析和评价益母草文献研究现状及其在疾病中的应用。结果共纳入益母草相关文献7 040篇,其中:益母草饮片文献4 653篇,中成药文献1 017篇,原料药文献648篇,兽医学文献722篇。益母草相关的中成药研究文献量呈三段式增长,发表量居前12位的杂志均为中文期刊,发表文献中出现频次最高的前三种中成药剂型分别是冲剂/颗粒、注射液和胶囊。中成药文献中报道益母草注射液263篇,含48篇基础研究,主要涉及子宫收缩、降低全血黏度、改善心肌缺血及其再灌注损伤、改善淋巴微循环等的作用;临床研究211篇,涉及产后出血和流产后出血,冠心病、脑梗塞、心力衰竭、心肌缺血等。结论益母草中成药文献远少于传统中药汤剂研究。冲剂/颗粒及注射液可能是益母草在临床使用中的优势剂型。产后出血可能是益母草注射液在临床使用中的优势病种。益母草注射液有多种药理作用,但临床研究文献证据级别较低,急需进一步深入开展高质量临床研究,为益母草注射液的临床实践提供高质量证据。
Objective To analyze the current status of studies related to motherwort a traditional Chinese herb medicine, and its application in prevention and treatment of diseases. Methods We searched CBM, CNKI, WanFang Data, EMbase and Ovid （MEDLINE） from inception up to August 26th, 2016. Two reviewers independently screened literature. Then the included studies were categorized by publication time, published journals and research topics, and a descriptive analysis was conducted. Results 7 040 studies were included, of which 4 653 were on decoction pieces, 1017 on motherwort patent formula, 648 on herbal medicine and 722 on animal studies. A ＂triple-stage＂ increasing tendency was found in numbers of published studies. The top twelve journals publishing papers about motherwort were all Chinese journals. The top three high-frequently used prescription forms were electuary/granule, injection, and capsule. 263 papers about Chinese patent medicine mentioned motherwort injection, in which 48 were fundamental studies that reported the effects such as promoting uterus contraction, reducing whole-blood viscosity, improving myocardial ischemia, reperfusion injury and lymphatic microcirculation and 211 were clinical studies about the effectiveness and safety of motherwort injection on postpartum hemorrhage, post-abortion hemorrhage, coronary heart disease, cerebral infarction, heart failure and myocardial ischemia. Conclusion Studies on motherwort patent formula are fewer than that on decoction. Electuary/granule and injection are ascendant formulation ofmotherwort in clinical practice. The common indication of motherwort injection is postpartum hemorrhage. Motherwort injection was found to have multiple pharmacological effects but the levels and quality of evidence are low. More high-quality studies are required to provide strong evidence for clinical application of motherwort injection in future.
出处
《中国循证医学杂志》
CSCD
2017年第1期94-101,共8页
Chinese Journal of Evidence-based Medicine
基金
四川省科技计划项目(编号:2014SZ0139)
四川省教育厅自然科学一般项目(编号:132130320)
