摘要
目的近几十年,肌肉型乙酰胆碱受体(nicotinic acetylcholine receptors,nAChRs)成为神经生理学、药理学、药物设计及相关疾病研究的重要靶点。包括横纹肌肉瘤、小儿软组织瘤、肌源性紊乱等疾病都与肌肉型nAChRs的异常有关。因此寻找针对肌肉型nAChRs的特异性探针,对于研究受体的结构、功能及相关疾病发病机理与治疗药物研发至关重要。方法通过查阅相关文献对近年来发现的特异作用于肌肉型nAChRs的生物毒素进行了综述。结果与结论自然界中存在许多天然生物毒素,能特异作用于肌肉型nAChRs,这些毒素对于研究肌肉型nAChRs的结构和功能,以及相关疾病的诊断和治疗有着非常重要的应用价值。
Objective In recent decades, muscle-type nicotinic acetylcholine receptors（nAChRs） are explored as the research target of neurophysiology, pharmacology, drug design and related diseases research. For example ,rhabdomyosarcoma, a pediatric soft-tissue cancer, muscle tissue associated with various neurogenic and myogenic disorders are all related to the pathological expression of muscle-type nAChRs. Therefore, searching the specific probes to target muscle type nAChRs is crucial for the study on the structure, function and the pathogenesis of the muscle-type nAChRs, and also important for the discovery of drug to treat nAChRs related diseases. Methods This paper has reviewed research progress of biological toxins targeting muscle-type nAChRs in recent years. Results and Conclusions In nature, there are many biotoxins with pontential action on muscle-type nAChRs, and they can play an important role in studying the structure and functions of muscle-type nAChRs, as well as the diagnosis and treatment of related diseases.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2017年第1期90-98,共9页
Journal of Shenyang Pharmaceutical University
基金
国家自然科学基金资助项目(41366002)
长江学者和创新团队发展计划资助项目(IRT_15R15)
关键词
肌肉型乙酰胆碱受体
芋螺毒素
蛇毒
蜘蛛毒素
水母毒素
生物碱毒素
muscle type nicotinic acetylcholine receptors
conotoxins
snake venom toxin
spider venom toxin
jellyfish venom toxins
alkaloids
