摘要
目的考察天竺黄炮制对冰片有效成分体外溶出的影响,初步探索天竺黄炮制冰片的机理。方法以不同比例天竺黄炮制冰片,采用转篮法进行体外溶出试验,气相色谱法进行冰片中龙脑和异龙脑含量测定,考察经不同比例的天竺黄炮制前后冰片有效成分体外溶出行为差异。结果经天竺黄炮制后,冰片有效成分溶出显著增强,不同比例天竺黄促进冰片溶出程度由大到小依次为:冰片-天竺黄(2∶1)>冰片-天竺黄(1∶2)>冰片-天竺黄(1∶1)。结论采用天竺黄炮制冰片能够显著促进冰片有效成分的溶出,且冰片与天竺黄比例为2∶1为最佳。
Objective The mechanism of processing borneol by tabasheer was explored preliminarily by investigating the influence of processing on dissolution of effective constituent in bomeol. Methods Borneol was processed by different varying proportions of tabasheer. Dissolution test was conducted according to China Phannacopeia 2015, first section. GC Chromatography was adopted to determination the effective constituent in different processing samples. Results The dissolution of effective constituent in borneol increased significantly after processing. The sequence of dissolution speed was borneol - tabasheer （2 ： 1） 〉 borneol - tabasheer （1 ： 2） 〉 borneol - tabasheer （1 ： 1）. Conclusion Processing by tabasheer could increace the dissolution ofborneol, the optimal mass ratio ofborneol- tabasheer was 2 ： 1.
出处
《现代中药研究与实践》
CAS
2016年第6期50-52,共3页
Research and Practice on Chinese Medicines
基金
陕西省重点科技创新团队计划项目(2012KCT-18):中药新型给药创新团队
西安市科技计划项目:临床使用天竺黄炮制冰片的机理研究(SF1419)
关键词
蒙药
天竺黄
冰片
炮制
溶出度
Traditional Mongolian Medicine
tabasheer
bomeol
processing
dissolution rate
