摘要
目的探讨急性期带状疱疹患者的临床特征与T细胞亚群的相关性。方法选择台州恩泽医疗中心路桥医院皮肤科2014年1月—2015年12月急性带状疱疹患者82例作为研究对象,收集患者的临床资料,流式细胞仪检测外周血CD4^+T细胞、CD8^+T细胞和CD3^+T细胞比例,计算CD4和CD8比值。结果≥60岁带状疱疹患者的病情评分、红斑面积、疼痛程度、水疱数目、水疱簇数和<60岁比较差异无统计学意义(P>0.05)。≥60岁带状疱疹患者CD8^+%和CD3^+%低于<60岁患者(P<0.05),≥60岁带状疱疹患者CD4/CD8高于<60岁患者(P<0.05)。重度带状疱疹患者的病情评分、红斑面积、疼痛程度、水疱数目、水疱簇数均高于轻中度患者(P<0.05)。重度带状疱疹患者CD3^+%高于轻中度患者(P<0.05),重度带状疱疹患者CD4^+%、CD8^+%和CD4/CD8和轻中度患者比较差异无统计学意义(P>0.05)。CD4^+%与急性带状疱疹的水疱时间和水疱簇数呈线性相关(P<0.05),CD8^+%与急性带状疱疹的疼痛时间、水疱部位、水疱时间和水疱簇数呈线性相关(P<0.05),CD3^+%与急性带状疱疹的疼痛时间、水疱部位、水疱时间、病情评分、水疱簇数和水疱数目呈线性相关(P<0.05),CD4/CD8与急性带状疱疹的年龄、水疱时间、红斑面积呈线性相关(P<0.05)。结论急性期带状疱疹的临床特征和T细胞亚群的关系密切。
Objective To investigate the correlation of the clinical features with T cell subsets in patients with acute herpes zoster. Methods The clinical data of 82 patients with acute herpes zoster in Taizhou Enze Medical Center Bridge Hospital from January,2014 to December,2015 were reviewed. Flow cytometry was used to detect peripheral blood CD4＋ T cells,CD8＋ T cells and CD3＋ T cell ratio,and the ratio of CD4 and CD8 was calculated. Results The herpes zoster condition score, the area of redness, pain, the number of blisters, the number of blisters clusters of patients aged 60 or over was not statistically different from patients less than 60 years of age （ P 〉 0.05 ）. The CD8 ＋ % and CD3 ＋ % of patients aged 60 or over with herpes zoster were lower than that of patients less than 60 years of age （ P 〈 0.05 ）, the CD4/CD8 of patients aged 60 or over with herpes zoster was higher than that of patients less than 60 years of age（ P 〈 0.05 ）. The condition score, area of erythema, pain, number of blisters, number of blisters clusters in severe herpes zoster patients were higher than those in mild to moderate patients（P 〈0.05）. The CD3 ＋% of severe herpes zoster patients was higher than that in mild to moderate patients（ P 〈 0.05 ）, the CIM ＋% ,CD8 ＋% and CD4/CD8 in severe herpes zoster patients were no significant difference with mild to moderate patients（ P 〉 0.05 ）. CD4 ＋% was linear correlation with blisters time and blisters cluster number of acute herpes zoster（ P 〈 0.05 ）, CD8 ＋ % was linear correlation with pain time, blisters parts, blisters time and blisters cluster number of acute herpes zoster（ P 〈 0.05 ）, CD3 % as linear correlation with pain time, parts of blisters, time of blisters, condition score, blisters clusters number and blisters number of acute herpes zoster（ P 〈 O. 05 ）, CIM/CD8 was linear correlation with age, blisters time, erythema area of acute herpes zoster（ P 〈 0.05 ）. Conclusion The clinical features of acute herpes zoster are closely related with T cell subsets.
作者
蔡玲琴
朱希聪
张灵鹏
张为
王锰
CAI Ling-qin ZHU Xi-cong ZHANG Ling-peng et al(Department of Dermatology, Luqiao Hospital of Taizhou Enze Medical Center （ Group ）, Taizhou, Zhejiang 318000, China)
出处
《中华全科医学》
2017年第1期39-41,共3页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2011KYA124)
