摘要
目的探讨乳腺癌基因-1(BRCA1)和肿瘤相关抗原(CA125)在子宫内膜癌(EC)中的表达及其临床意义。方法选取2014年1月—2016年2月在德阳市人民医院就诊的EC患者56例,非典型子宫内膜增生患者32例,子宫肌瘤患者26例,采用免疫组织化学法检测BRCA1和CA125在不同子宫内膜组织中的表达,并对EC患者在不同病理因素下BRCA1和CA125的表达差异进行分析。结果 BRCA1和CA125在EC、非典型子宫内膜增生及子宫肌瘤患者子宫内膜中的阳性表达率分别为32.14%、75.00%、96.15%和69.64%、53.13%、7.69%,其中BRCA1在EC患者中的表达显著低于其他2组(P<0.05),而CA125在EC患者中的表达显著高于其他2组(P<0.05)。BRCA1的阳性表达率在手术病理分期、组织分化、淋巴有无转移的组间差异均具有统计学意义(P<0.05),但与肌层浸润程度无关;CA125的阳性表达率与不同手术病理分期、组织分化、肌层浸润有关,而与淋巴结转移无关;子宫内膜组织中BRCA1和CA125的表达呈负相关(r=-0.319,P=0.013)。结论 EC患者子宫内膜中BRCA1呈低表达,CA125呈高表达,且BRCA1和CA125在EC中的水平变化与组织分化程度、病理分期等指标有关,可用于评估EC恶性程度,在临床诊断中具有重要意义。
Objective To investigate the expression and clinical significance of breast cancer gene-1 （ BRCAI ） and tumor associated antigen（ CA125 ）in endometrial carcinoma（EC）. Methods A total of 56 patients with EC were selected from Deyang People＇s Hospital from January,2014 to February,2016. Meanwhile, another 32 cases with atypical endometrial hyperplasia and 26 cases with uterine fibroids were selected as control group. The expressions of BRCA1 and CA125 in different endometrial tissues were detected by immunohistochemistry,and the expressions of BRCAI and CA125 under different pathological factors were analyzed. Results The positive rates of BRCA1 and CA125 expression in the endometri- um of patients with EC, atypical endometrial hyperplasia or uterine fibroids were 32. 14% , 75. 00%, 96. 15% and 69.64% ,53.13% ,7.69% respectively. The expression of BRCA1 in EC was significantly lower than that of the other two groups （P 〈 0.05）, but the level of CA125 in E C was significantly higher than that of the other two groups （P 〈 0.05 ）. The positive rate of BRCA1 expression in clinical stage, histological differentiation,lymphoid metastasis status all had sta- tistical significance（P 〈 0.05 ）, but there was no relationship between the BRCA1 expression and myometrial invasion. The expression of CA125 in EC was associated with the clinical stage, histological differentiation, myometrial invasion, but was not related to the lymphoid metastasis status. The expression of BRCA1 and CA125 in endometrial tissue was nega- tively correlated（r = -0. 319 ,P =0. 013）. Conclusion BRCA1 has low expression and CA125 is highly expressed in EC. The expression of BRCA1 and CA125 in EC are related to the clinical stage, histological differentiation and other indi- cators, and it can be used to assess the degree of malignancy of EC and it＇ s of great significance in clinical diagnosis. Key words： Endometrial carcinoma; BRCA1 ; CA125 ; Immunohistochemistry
作者
刘睿倩
LIU Rui-qian.(Department of Ob- stetrics and Ccynecology ,Deyang People＇s Hospital ,Deyang ,Sichuan 618000 ,China)
出处
《中华全科医学》
2017年第1期88-91,共4页
Chinese Journal of General Practice
