摘要
目的探讨术前规律口服非那雄胺对重度前列腺增生症在电切术中、术后出血的影响,寻找降低手术风险提高安全性的围术期治疗措施。方法自2013年3月至2015年3月对来本院就诊的前列腺增生(benign prostatic hyperplasia,BPH)患者,随机将前列腺增生体积在60ml及以上的患者分为实验组和对照组,实验组术前规律口服非那雄胺5mg,1次/天×3个月,同期口服盐酸坦索罗辛缓释胶囊0.2mg,1次/天;对照组术前规律口服盐酸坦索罗辛缓释胶囊0.2mg,1次/天×3个月。结果实验组54例,服药前前列腺体积(76.7±5.8)ml,服药后前列腺体积(62.8±3.5)ml,平均手术时间(86±7)分钟,术中出血(180±30)ml,术后膀胱冲洗时间(3.5±0.5)天。对照组53例,服药前前列腺体积(77.4±4.9)ml,服药后前列腺体积(77.8±5.2)ml,平均手术时间(105±10)分钟,术中出血(320±50)ml,术后膀胱冲洗时间(5.5±0.5)天。实验组手术时间、术中出血、术后膀胱冲洗较对照组均明显减少(P<0.05)。结论围术期规律口服非那雄胺可缩小前列腺体积,减少术中出血、术后渗血,有效提高前列腺电切手术安全性。
Objective To investigate whether the incidence of perioperative bleeding of transurethral resection of prostate（ TURP） could be decreased by the preoperative administration of finasteride in the severe benign prostatic hyperplasia（ BPH） patients. This study is to discover proper measures to reduce the surgical risk and improve the security of TURP. Methods We collected clinical data of patients with BPH in our hospital from march 2013 to march2015. Patients with the volume of the prostate more than 60 ml were included and randomly divided into the experimental group and the control group. In the experimental group,patients received the preoperative treatment of 5mg finasteride and 0. 2mg tamsulsosin hydrochloride capsules once daily for three months,while preoperative 0. 2mg tamsulsosin hydrochloride capsules once daily for three months in the control group. Results In the experimental group,prostate volume of patients（ 54 cases） before or after medication were respectively（ 76. 7 ± 5. 8） ml and（ 62. 8 ± 3. 5）ml,the average operation time was（ 86 ± 7） minutes,intraoperative bleeding was（ 180 ± 30） ml,postoperative bladder irrigation time was（ 3. 5 ± 0. 5） days. In the control group,prostate volume of patients（ 53 cases） before or after medication were respectively（ 77. 4 ± 4. 9） ml and（ 77. 8 ± 5. 2） ml,the average operation time was 105 ± 10 minutes,intraoperative bleeding was（ 320 ± 50） ml,postoperative bladder irrigation time was（ 5. 5 ± 0. 5） days. The operation time,intraoperative bleeding and postoperative bladder irrigation time of the experimental group were obviously decreased compared with the control group（ P〈0. 05）. Conclusions Regular perioperative administration of finasteride can significantly reduce the volume of the prostate,reduce the intraoperative bleeding and postoperative errhysis,and effectively improve the security of TURP.
出处
《泌尿外科杂志（电子版）》
2016年第1期40-43,共4页
Journal of Urology for Clinicians(Electronic Version)
关键词
非那雄胺
前列腺增生症
电切术
安全性
Finasteride
Benign prostatic hyperplasia
Transurethral resection of prostate
Security
