摘要
目的探讨肝硬化并发静脉血栓形成的危险因素。方法回顾性分析肝硬化并发门脉系统血栓和/或下肢深静脉血栓(DVT)患者与肝硬化非血栓患者的年龄、性别、糖尿病史、高血压病史、肝硬化病因;比较两组患者的血红蛋白(HGB)、血小板(PLT)、白蛋白(ALB)、空腹血糖(Glu)、糖化血红蛋白(HBAlc)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转肽酶(γ-GT)、血清总胆红素(TBIL)、直接胆红素(DBIL)、胆汁酸(TBA)、肌酐(Cr)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib)、D-二聚体(D-dimer)。结果血栓组与对照组性别、年龄、糖尿病史、高血压史、肝硬化病因比较,差异无统计学意义(P>0.05);Logistic回归模型分析显示,D-二聚体、血小板是肝硬化合并静脉血栓形成的独立危险因素(P<0.05)。结论肝硬化患者较易合并静脉血栓性疾病,加强对患者D-二聚体、血小板的监测,可警惕肝硬化合并静脉血栓形成的可能,使患者得到早期诊断和治疗。
Objective To investigate the risk factors of patients with cirrhosis and venous thrombosis. Methods The age,gender,diabetes mellitus,hypertension and causes of cirrhosis were contrasted between thrombosis group and control group. The hemoglobin（HGB）,platelets（PLT）,albumin（ALB）,glucose（Glu）,glycated hemoglobin（HBAlc）,alanine aminotransferase（ALT）,γ-glutamyl peptidase（γ-GT）,serum total bilirubin（TBIL）,direct bilirubin（DBIL）,bile acid（TBA）,creatinine（Cr）,prothrombin time（PT）,activated partial thrombin time（APTT）,fibrinogen（Fib）,D-dimer were compared between two groups. Results There were no significant difference in sex,age,history of diabetes,history of hypertension and causes of cirrhosis between thrombosis group and control group（P〉0. 05）. Logistic regression analysis showed that D-dimer and PLT were independent risk factors of patients with cirrhosis and venous thrombosis（P〈0. 05）. Conclusion The patients with cirrhosis suffered from venous thrombosis frequently. Pay more attention to D-dimer and PLT,we could diagnose and treat that patients with cirrhosis and venous thrombosis early.
出处
《胃肠病学和肝病学杂志》
CAS
2017年第1期17-19,共3页
Chinese Journal of Gastroenterology and Hepatology
