摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一组除外酒精和其他明确肝损伤因素所致的以肝细胞内脂肪过度沉积的临床病理综合征。阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)是睡眠期间反复发生的以部分或完全上气道阻塞为特征的呼吸紊乱,常伴有胸内负压增加、片段睡眠及间歇性低氧血症。而间歇性缺氧是其主要的病理生理。目前已有研究认为慢性间歇性缺氧(chronic intermittent hypoxia,CIH)与NAFLD整个疾病谱密切相关。本文将通过国内外研究对CIH与NAFLD相关性作一概述。
Non-alcoholic fatty liver disease（NAFLD） is a group of clinic pathological syndrome of excessive fat deposition in hepatocyte which is caused by other definite hepatic impairment factors except alcohol. Obstructive sleep apnea syndrome（OSAS） is a kind breathing disorder which is featured of partial or complete upper airway obstruction and happens in sleeping period repeatedly. It normally accompanies with intrapleural negative pressure increasing,fragment sleep and intermittent hypoxemia. The chronic intermittent hypoxemia（CIH） is its main pathophysiology. Existed studies believe that CIH has close relation with the disease spectrum of NAFLD. This paper summarized the CIH and NAFLD through the studies in China and abroad.
出处
《胃肠病学和肝病学杂志》
CAS
2017年第1期107-109,共3页
Chinese Journal of Gastroenterology and Hepatology
