摘要
目的比较氨磺必利与利培酮对女性首发精神分裂症患者认知功能的疗效，为女性精神分裂症患者临床用药提供参考。方法采用随机数字表法将天津市安定医院符合《国际疾病分类（第10版）》（ICD-10）诊断标准的100例女性首发精神分裂症患者分为氨磺必利组和利培酮组各50例，分别给予氨磺必利和利培酮治疗6周。于治疗前和治疗6周后采用阳性与阴性症状量表（PANSS）评定疗效，采用词汇流畅性测验（VFT）、数字广度测验（DST）和威斯康辛卡片分类测试（WCST）评定认知功能。结果共78例患者完成研究，利培酮组与氨磺必利组脱落人数差异无统计学意义（χ=3．730，P=0．054）。治疗前两组PANSS、VFT、DST及WCST评分差异均无统计学意义（P均〉0．05）。治疗6周后，两组PANSS评分均低于治疗前，VFT及DST评分均高于治疗前，差异均有统计学意义（P均〈0．01）；但两组PANSS、VFT及DST评分差异均无统计学意义（P均〉0．05）；利培酮组的持续性错误数和氨磺必利组的正确应答数、持续性错误数均较治疗前改善，但利培酮组的非持续性错误数较治疗前变差，差异均有统计学意义（P均〈0．05）；氨磺必利组的正确应答数评分高于利培酮组[（61．79±5．50）分vs．（65．86±5．19）分，t=-3．129，P=0．002]。结论氨磺必利与利培酮对女性首发精神分裂症患者精神症状的疗效相当，但氨磺必利对患者认知功能的改善略优于利培酮。
Objective To compare the efficacy on cognitive function between amisulpride and risperidone in treatment of female patients with first - episode schizophrenia and to provide reference for clinical treatment. Methods A total of 100 female patients with schizophrenia who met International Classification of Diseases, tenth edition （ICD - 10） from Tianjin Anding Hospital were randomly divided into the amisulpride group and the risperidone group by random number table. There were 50 cases in each group. All of the patients were treated for 6 weeks. Efficacy was assessed with Positive and Negative Syndrome Scale （ PANSS）, cognitive function was assessed with Verbal Fluency Test （ VFT）, Digit Span Test （DST） and Wisconsin Card Sorting Test （WCST） at the baseline and 6 weeks after treatment. Results Finally, 78 cases completed the study, the patients dropped out of the study had no statistical significance between the two groups （χ2 = 3. 730, P = 0. 054）. The differences of PANSS, VFT, DST and WCST scores between the two groups were not statistically significant at the baseline （ all P 〉 0.05 ）. After 6 weeks treatment, the scores of PANSS in both groups decreased compared with the baseline （ all P 〈 0.01 ） , the scores of VFT and DST in both groups increased compared with the baseline （all P 〈 0. 01 ）. While the differences of PANSS, VFT and DST scores between the two groups were not statistically significant （ all P 〉 0. 05）. In the terms of WCST, the risperidone group showed improvement in perseverative errors but was worse in non- perseverative errors compared with the baseline（ all P 〈0.05 ） , amisulpride group showed improvement in correct responses and perseverative errors compared with the baseline （all P 〈 0.05 ）. However, the score of correct responses in the amisulpride group was higher than that of the risperidone group [ （61.79 ± 5.50） vs. （65.86 ±5.19）, t = - 3. 129, P = 0.002 ]. Conclusion The efficacy of amisulpride and risperidone in the treatment of psychiatric symptom for female patients with schizophrenia are similar. But amisulpride is more effective on cognitive function than risperidone.
出处
《四川精神卫生》
2016年第6期530-533,共4页
Sichuan Mental Health
关键词
氨磺必利
利培酮
精神分裂症
认知功能
Amisulpride
Risperidone
Schizophrenia
Cognitive function
