摘要
为了解肝硬化 (LC)患者血清胰岛素样生长因子 (IGF - 1)、视黄醇结合蛋白 (RBP)水平变化及其与患者肝功能损伤的关系 ,用ELISA法和比浊法检测了 5 0例LC患者和 2 0例正常人的血清IGF - 1和RBP水平。LC患者血清IGF - 1和RBP水平均显著低于对照组 (P均 <0 0 1) ,且在肝功能分级中 ,随childA、B、C级的升高而递减 ,各组间比较差异有极显著意义 (P <0 0 5 )。表明 :IGF - 1和RBP是反映肝实质损害的灵敏指标 。
To investigate the levels of serum insulin-like growth factor (IGF-1) and retinol-blinding protein (RBP) and assess their role on heptic function injury in the case of liver cirrohosis. The serum IGF-1 and RBP were measured with ELISA method in serum samples collected from 20 healthy controls and 50 liver cirrhosis patients. Results showed that serum IGF-1 and RBP levels in liver cirrohosis patients were significantly lower than that in heathly controls ( P both<0 01). Comparisions among the levels of serum IGF-1 and RBP classified by liver function were shown the sequance of child A>child B>child C. This study suggests that the decrease of serum IGF-1 and RBP are closely associated with the liver function injury and they can reflect the severity of liver cirrhosis.
出处
《临床肝胆病杂志》
CAS
北大核心
2002年第4期237-238,共2页
Journal of Clinical Hepatology
