摘要
目的系统评价养血清脑颗粒治疗中风后抑郁的疗效及安全性,为临床药物治疗提供循证依据。方法利用计算机检索CNKI、中国生物医学文献数据库(CBM)、万方数据库、维普期刊数据库(VIP)、Pub Med、Cochrane Library等数据库,搜集养血清脑颗粒治疗中风后抑郁的随机对照试验,检索时限为从建库至2016年4月10日。指定2名评价员分别筛选文献并对所纳入研究进行方法学质量评价,然后提取数据并利用RevMan5.3软件完成Meta分析。结果最终10项随机对照试验纳入本Meta分析,包含1035例患者。养血清脑颗粒联合抗抑郁药治疗中风后抑郁≥28 d后,有效率、降低HAMD评分及NIHSS评分的疗效均高于对照组(单独应用抗抑郁药)(P<0.05);而不良反应发生率与对照组比较差异无统计学意义(P>0.05)。养血清脑颗粒单独用药组的有效率、降低HAMD评分的疗效及不良反应发生率与对照组比较差异均无统计学意义(均P>0.05)。结论养血清脑颗粒能够有效改善中风后抑郁症状,且治疗效果与临床上常用的抗抑郁药基本相当,并具有良好的安全性。但还需要设计上更严谨的多中心、大样本、随机对照试验来进一步证实此结论。
Objective： To systematically assess the efficacy and safety of Yangxue Qingnao Granule with or without antidepressants for post-stroke depression （PSD）. Methods： CNKI, Wanfang Data, VIP, CBM, PubMed, and Cochrane Library were searched for randomized controlled trials （RCT） of Yangxue Qingnao Granule in treating post-stroke depression from the time that the database was built to April 10,2016. Two researchers screened out the eligible studies and evaluated the quality of the included studies,then extracted date and made a Meta- analysis by RevMan5.3software. Results： 10 RCTs involving 1035 patients entered the inclusion criteria. The Meta-analysis showed that： compared with the control group （treated with antidepressants）,the treatment group （treated with Yangxue Qingnao Granule with antidepressants for at least 28 days） had higher efficiency,less HAMD and NIHSS scores （all P〈 0.05）. There was no statistical difference in terms of the occurrences of adverse effects between the control group and treatment group （P〉0.05）. However,there was no statistical difference on efficiency, HAMD scores and occurrences of side effects between Yangxue Qingnao Granule and antidepressants （all P 〉 0.05）. Conclusion： On improving the symptoms of post-stroke depression, Yangxue Qingnao Granule is efficient and safe. Additionally,it has the similar effects as antidepressants. However,this conclusion needs to be confirmed by more randomized controlled trials of multi-center and large sample study.
出处
《中国中医急症》
2017年第1期38-41,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
江苏省优势学科中西医结合专项基金
江苏省中医局基金资助项目(BE2016808)
2016江苏省省级名老中医药专家传承工作室建设
关键词
中风后抑郁
养血清脑颗粒
抗抑郁药
META分析
Post-stroke depression
Yangxue Qingnao Granule
Antidepressants
Meta-analysis
