摘要
目的:探讨布地奈德雾化吸入联合阿奇霉素序贯治疗小儿支原体肺炎的效果。方法:选取2015年2月—2016年8月收治的124例小儿支原体肺炎患者,按照随机数字表法分为2组,每组各62例。对照组患儿单纯给予阿奇霉素序贯治疗,观察组患儿给予阿奇霉素序贯疗法联合布地奈德雾化吸入治疗。观察并比较2组患儿的治疗效果、临床症状和体征的变化及不良反应发生情况。结果:治疗结束后,观察组患儿总有效率为95.16%(59/62),对照组为85.48%(53/62),2组的差异有统计学意义(P<0.05)。观察组患儿咳嗽、声嘶等症状消失时间显著短于对照组;2组患儿治疗后中性粒细胞绝对值、C反应蛋白等指标均有显著改善,且观察组改善程度明显优于对照组,差异均有统计学意义(P<0.05)。治疗过程中,观察组患儿不良反应发生率为6.45%(4/62),对照组为16.13%(10/62),观察组明显低于对照组,差异有统计学意义(P<0.05)。结论:小儿支原体肺炎的发病率较高,采用布地奈德雾化吸入联合阿奇霉素序贯治疗,能显著改善患儿症状,且不良反应较少。
OBJECTIVE： To probe into the effects of budesonide aerosol inhalation combined with azithromycin sequential therapy in treatment of children with mycoplasma pneumonia. METHODS： 124 children with mycoplasma pneumonia admitted from Feb. 2015 to Aug. 2016 were selected to be divided into two groups via the random number table,with 62 cases in each. The control group were treated with azithromycin sequential therapy, while the observation group additionally received budesonide aerosol inhalation. The clinical effects, changes of clinical symptoms and signs, and adverse drug reactions of two groups were observed and compred. RESULTS： Aftertreatment,the total effective rate of observation group was 95. 16%（ 59 /62）,and control group was 85. 48%（ 53 /62）,the difference was statistically significant（ P〈0. 05）. The disappearance time of cough and hoarseness of observation group were significantly lower than those of control group; indicators of absolute neutrophil count and Creactive protein in two groups improved significantly,and the observation group was better than that of control group,with statistically significant difference（ P〈0. 05）. During treatment,the incidence of adverse drug reactions of observation group was 6. 45%（ 4 /62）,significantly lower than that of control group [16. 13%（ 10 /62） ],with statistical significance（ P〈0. 05）. CONCLUSIONS： The incidence of mycoplasma pneumonia in children are relatively high,the use of azithromycin sequential therapy combined with budesonide inhalation can significantly improve the symptoms with few adverse drug reactions.
出处
《中国医院用药评价与分析》
2016年第11期1512-1514,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
阿奇霉素
序贯治疗
布地奈德
小儿支原体肺炎
Azithromycin
Sequential therapy
Budesonide
Children with mycoplasma pneumonia
