摘要
目的：研究硫酸镁对重度子痫前期患者剖宫产术后出血量及Toll样受体4（TLR4）水平的影响,并探讨其意义。方法：选取2013年9月—2015年9月湖北医药学院附属襄阳市第一人民医院收治的重度子痫前期患者100例,以随机数字表法分为观察组与对照组,每组各50例。行剖宫产术分娩胎儿后,对照组患者给予米索前列醇治疗,观察组患者在此基础之上给予硫酸镁治疗。记录并比较2组患者术后出血量、血压变化及不良反应;使用酶联免疫吸附测定法,检测并比较重度子痫前期患者血清中TLR4水平。结果：治疗后,对照组患者收缩压与治疗前的差异无统计学意义（P〉0.05）,而舒张压明显低于治疗前,差异有统计学意义（P〈0.05）;治疗后,观察组患者收缩压与舒张压均较治疗前明显降低,且明显低于对照组,差异均有统计学意义（P〈0.05）。观察组患者剖宫产术后0-2、2-24 h出血量及总出血量均明显低于观察组,差异均有统计学意义（P〈0.05）。治疗后,观察组外周血清TLR4水平明显低于对照组,差异有统计学意义（P〈0.05）。2组中有个别患者患者出现术后恶心、呕吐或轻微发热等,均在一般性支持治疗后自行缓解,无需特殊治疗,其余患者无明显不良反应。结论：硫酸镁可通过下调重度子痫前期患者血清TLR4的表达来达到治疗产后出血的目的,且效果显著,不良反应少,安全性较高。
OBJECTIVE： To study the effects of magnesium sulfate on bleeding volume and TLR4 level in pregnant women with severe preeclampsia after cesarean section,and to pro into the significance. METHODS： 100 patients with severe preeclampsia admitted into Xiangyang First People＇s Hospital Affiliated to Hubei University of Medicine from Sept. 2013 to Sept. 2015 were selected to be divided into observation group and control group via the random number table,with 50 cases in each. After cesarean section,the control group were treated with misoprostol,while the observation group additionally received magnesium sulfate based on the control group. The bleeding volume,changes of blood pressure and adverse drug reactions of two groups were recorder and compared. And the ELISA method was used to detect and compare the serum levels of TLR4 in the serum of women with severe preeclampsia. RESULTS：After treatment,there was no significant difference in systolic blood pressure between before and after treatment in control group（ P〉0. 05）,but diastolic blood pressure was lower than before treatment,the difference was statistically significant（ P〈0. 05）. The systolic pressure and diastolic pressure of the observation group were lower than before treatment,and the systolic and diastolic blood pressure in the observation group were lower than those in the control group,the difference was statistically significant（ P〈0. 05）. In control group,the amount of 0-2 h,the amount of2-24 h and the total amount of bleeding after cesarean section were higher than those in observation group,the difference was statistically significant（ P〈0. 05）. After treatment,the TLR4 level of peripheral serum in control group was higher than that in observation group,the difference was statistically significant（ P〈0. 05）. After treatment,individual patients had nausea,vomit and slight fever,which could be relieved after general support treatment; and the other patients had no obvious adverse drug reactions. CONCLUSIONS： Magnesium sulfate can reduce severe preeclampsia maternal serum TLR4 expression to achieve the purpose of treatment of postpartum hemorrhage,and the effects are significant with few adverse drug reactions and high safety; it is worth promoting.
出处
《中国医院用药评价与分析》
2016年第12期1659-1661,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
硫酸镁
重度子痫前期
剖宫产术
出血量
TLR4
Magnesium sulfate
Severe preeclampsia
Csarean section
Bleeding volume
TLR4
