摘要
目的观察预防性治疗季节性变应性鼻炎(AR)的疗效。方法选择变应原为蒿属花粉的中-重度持续性AR患者60例,随机分为预防性治疗组(以下简称治疗组)及对照组各30例,治疗组在花粉季开始前2周口服中药进行预防性治疗,对照组不予干预。花粉季开始后,2组患者均口服中药治疗6周。随访观察并记录2组患者流涕、鼻痒、喷嚏、鼻塞、眼痒症状评分及鼻部体征,并定期采用鼻结膜炎相关生活质量问卷评价AR对生活质量的影响。结果在花粉季高峰时治疗组流涕、鼻痒、鼻塞症状评分及RQLQ评分均轻于对照组,差异具有统计学意义(P<0.01)。整个花粉季期间,治疗组眼痒症状轻于对照组,差异具有统计学意义(P<0.01);治疗组鼻部体征总体程度轻于对照组,差异具有统计学意义(P<0.05)。结论花粉季前2周预防性治疗秋季蒿属花粉过敏的AR患者,可有效缓解患者临床症状,提高生活质量。
Objective To investigate the effect of prophylactic treatment on seasonal allergic rhinitis（ AR）. Methods 60 patients with moderate-severe persistent allergic rhinitis based on mugwort allergen were randomly divided into two groups,with 30 cases each in prophylactic group and control group respectively. Patients in prophylactic group were treated with traditional Chinese medicine 2 weeks before pollen season,and control group was given no treatment. At the beginning of pollen season,two groups accepted traditional Chinese medicine for 6 weeks. The symptom score of nose and eye was recorded by using a visual analogue scale. The quality of life was evaluated by rhinoconjunctivitis quality of life questionnaire（ RQLQ） periodically. Results In the peak pollen season,the symptom scores of nasal congestion,nasal itching,eye itching and nasal signs were significantly lower in the prophylactic group than those in the control group. The differences between the two groups were significant（ P〈0. 01）. During the whole pollen season,the eye itching was lighter than that of the control group,the difference was significant（ P〈0. 01）,the symptom scores of nasal signs was lighter than the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Pretreatment two weeks before pollen treatment can relieve the clinical symptoms,and improve the life quality of allergic rhinitis based on mugwort allergen.
作者
罗超
刘巧平
刘建华
闫占峰
周蕾
矫璐璐
巩政
耿燕
LUO Chao LIU Qiaoping LIU Jianhua YAN Zhanfeng ZHOU Lei JIAO Lulu GONG Zheng GENG Yan(Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700 Beijing University of Chinese Medicine)
出处
《现代中医临床》
2016年第6期39-42,共4页
Modern Chinese Clinical Medicine
基金
北京中医药大学自主选题项目(No.2016-JYB-QNJSZX008)
关键词
鼻炎
变应性
季节性
预防性治疗
rhinitis
allergic
seasonal
prophylactic treatment
