摘要
目的:通过研究吸烟对种植体周围炎患者龈沟液中白细胞介素-1β表达的影响,探讨吸烟,白细胞介素-1β与种植体周围炎之间可能的关系。方法:选取我院牙周粘膜科就诊患有种植体周围炎的患者30例,其中不吸烟患者15例,吸烟患者15例。各选取其一颗种植体及一颗对侧健康天然牙,共60颗,分为四组:A组,吸烟患者种植牙;B组,不吸烟患者种植牙;C组,吸烟患者对侧天然牙;D组,不吸烟患者对侧天然牙。测量种植体改良龈沟出血指数(modified sulcus bleeding index,m SBI)、探诊深度(probing depth,PD),根据X线片测定牙槽骨吸收(alveolar bone loss,a BL)程度。并用ELISA法定量检测种植体及天然牙龈沟液中的白细胞介素-1β(IL-1β)。结果:PD、a BL、m SBI三个指标,吸烟者种植体组(A组)均高于不吸烟者种植体组(B组),但P>0.05,其差异无统计学意义。IL-1β在吸烟者均(A组、C组)明显高于不吸烟者(B组、D组),并且吸烟者种植体(A组)高于吸烟组天然牙(C组),且P<0.05,差异有统计学意义。结论:吸烟会导致种植体周围炎和健康天然牙的龈沟液中白细胞介素-1β表达升高,同时吸烟对于种植体的不利影响可能高于天然牙,提示吸烟是牙周炎和种植体周围炎发生、发展的重要危险因素。
Objective：To evaluate the effect of smoking on periimplantitis.Methods：Thirty dental implants and thirty natural teeth were divided into four groups：A（dental implants with smoking）,B（dental implants without smoking）,C（natural teeth with smoking）,D（natural teeth without smoking）.The periodontal index（PD、mSBI、aBL）,levels of IL-1β in gingival crevicular fluid（GCF） periimplant crevicular fluid（PICF） were examined,and statistic analysis was maken.Results：PD、mSBI、aBL in dental implants with smoking（group A） was higher than that in dental implants without smoking（group B）（P〈0.05）.IL-1β in dental implants with smoking（group A）was higher than that in dental implants without smoking（group B） and natural teeth with smoking（group C）（P〈0.05）.IL-1β in group C was higher than that in group D（P〈0.05）.Conclusions：Smoking is a important dangerous factor for periimplantitis and periodontitis.And smoking may be more often associated with damage in dental implant than in natural tooth.
出处
《中华老年口腔医学杂志》
2016年第6期339-342,共4页
Chinese Journal of Geriatric Dentistry
基金
新疆医科大学第一附属医院自然科学-青年基金(项目编号:2014ZRQN08)
新疆维吾尔自治区自然科学基金(项目编号:2016D01C251)
