摘要
目的探讨生长抑素联合特利加压素作用于肝硬化急性食管胃底静脉曲张破裂出血的临床效果。方法 50例肝硬化急性食管胃底静脉曲张破裂出血患者,随机分为观察组（26例）和对照组（24例）。对照组给予生长抑素治疗,观察组给予生长抑素联合特利加压素治疗。比较两组临床效果。结果观察组止血时间为（6.1±2.4）h,短于对照组的（8.3±2.8）h,差异有统计学意义（t=2.9900,P=0.0044〈0.05）。观察组输血量为（3.8±2.0）U,少于对照组的（5.7±2.4）U,差异有统计学意义（t=3.0499,P=0.0037〈0.05）。观察组再出血率为11.54%（3/26）,低于对照组的37.50%（9/24）,差异有统计学意义（χ~2=4.6116 P=0.0137〈0.05）。观察组死亡率为7.69%（2/26）,低于对照组的29.17%（7/24）,差异有统计学意义（χ~2=3.8891,P=0.0037〈0.05）。观察组在治疗中出现腹泻1例,不良反应发生率为3.85%;对照组在治疗中出现腹部痉挛性疼痛1例,不良反应发生率为4.17%;两组不良反应发生率比较差异无统计学意义（χ~2=0.0033,P=0.9081〉0.05）,两组患者未经处理不良反应均自动消失,未对治疗产生负面影响。结论在肝硬化急性食管胃底静脉曲张破裂出血的治疗中,采用生长抑素联合特利加压素治疗整体效果良好,值得在临床实践中予以借鉴并推广。
Objective To investigate clinical effect by somatostatin combined with terlipressin in the treatment of liver cirrhosis acute esophagogastric variceal bleeding.Methods A total of 50 patients with liver cirrhosis acute esophagogastric variceal bleeding were randomly divided into observation group（26 cases） and control group（24 cases）.The control group received somatostatin for treatment,and the observation group received somatostatin combined with terlipressin for treatment.Clinical effects were compared between the two groups.Results The observation group had shorter hemostasis time as（6.1± 2.4） h than（8.3± 2.8） h in the control group,and the difference had statistical significance（t=2.9900,P=0.00440.05）.The observation group had less blood transfusion volume as（3.8± 2.0） U than（5.7± 2.4） U in the control group,and the difference had statistical significance（t=3.0499,P=0.00370.05）.The observation group had lower recurrent bleeding rate as 11.54%（3/26）than 37.50%（9/24）,and the difference had statistical significance（χ~2=4.6116,P=0.01370.05）.The observation group had lower mortality rate as 7.69%（2/26） than 29.17%（7/24） in the control group,and the difference had statistical significance（χ~2=3.8891,P=0.00370.05）.There was 1 case with diarrhea in the observation group,with incidence of adverse reactions as 3.85%.The control group has 1 case with abdominal spasmodic pain during treatment,with incidence of adverse reactions as 4.17%.There was no statistically significant difference of incidence of adverse reactions between the two groups（χ~2=0.0033,P=0.90810.05）.Adverse reactions in both groups were relieved without special treatment,and they showed no negative influence on treatment.Conclusion Implement of somatostatin combined with terlipressin shows excellent effect in the treatment of liver cirrhosis acute esophagogastric variceal bleeding,and this method is worth clinical application,reference and promotion.
出处
《中国实用医药》
2016年第33期108-109,共2页
China Practical Medicine
