摘要
目的研究瑞舒伐他汀对慢阻肺合并肺动脉高压患者体内炎症因子水平影响。方法将我院80例稳定期慢阻肺合并肺动脉高压患者,随机分为对照组40例,采用常规对症治疗;治疗组患者40例,在对照组治疗基础上口服瑞舒伐他汀进行治疗。比较两组患者治疗前后PAH、6MWD、血清IL-6及半乳糖凝集酶-3指标变化。结果治疗后两组患者PAPm、PAPs均有所下降,6MWD有所提高,但对照组患者PAPm、PAPs下降水平低于治疗组,6MWD提高水平低于治疗组,差异显著(P<0.05);治疗后两组患者血清IL-6、半乳糖凝集酶-3指标均有所下降,对照组患者下降水平低于治疗组,差异显著(P<0.05)。结论给予慢阻肺合并肺动脉高压患者瑞舒他汀治疗,可降低肺动脉压力及低炎症因子水平,提高患者6 min步行距离,改善肺功能,提高患者生活质量。
Objective： To study the influence of rosuvastatin on levels of inflammatory factors of patients with chronic obstructive pulmonary disease（ COPD） combined with pulmonary hypertension（ PH）. Methods： Eighty patients with stable COPD combined with PH were enrolled in this study,and were randomly divided into control group（ n = 40） and treatment group（ n = 40）. The control group was treated with conventional therapy,and the treatment group was treated with rosuvastatin on the basis of the control group. The changes of PAH,6MWD,serum IL-6 and Gal-3 in the two groups before and after treatment were compared. Results： After treatment,the levels of PAPm and PAPs decreased and the level of6 MWD increased in the two groups. The decreased levels of PAPm and PAPs in control group were significantly lower than those of treatment group,and the increased level of 6MWD was significantly lower than those of the treatment group（ P〈0. 05）; After treatment,serum IL-6 and Gal-3 in the two groups decreased,and the decreased levels in control group were significantly lower than those of the treatment group（ P〈0. 05）. Conclusion： Rosuvastatin in the treatment of patients with COPD combined with PH can obviously reduce PAPs and low levels of inflammatory factors,increase patients＇ 6min waking distance,improve lung function and enhance the quality of life for patients.
作者
孙永彪
任宏强
耿玉荣
赵磊
刘红阳
马克涛
张忠双
SUN Yong-biao REN Hong-qiang GENG Yu-rong ZHAO Lei LIU Hong-yang MA Ke-tao ZHANG Zhong-shuang(2014 Clinical Medical Undergraduate of Medical College of Shihezi University The First Affiliated Hospital of Medical College of Shihezi University Dept. of Basic Medicine of Medical College of Shihezi University, Shihezi 832000,China)
出处
《泰山医学院学报》
CAS
2016年第11期1224-1226,共3页
Journal of Taishan Medical College
关键词
瑞舒伐他汀
慢阻肺
肺动脉高压
炎症因子水平
rosuvastatin
chronic obstructive pulmonary disease
pulmonary hypertension
levels of inflammatory factors
