摘要
目的:探讨抽动障碍患儿病情严重程度与其动态脑电图及头颅核磁改变的相关性。方法:对125例抽动障碍患儿进行耶鲁评分、动态脑电图以及头颅核磁检查。按抽动障碍患儿动态脑电图、头颅核磁检查结果将其分为正常组及异常组,比较不同组患儿的耶鲁评分;按抽动患儿耶鲁评分,将其分为轻、中、重症三组,比较不同组患儿的动态脑电及头颅核磁异常率,以探讨动障碍患儿病情严重程度与其动态脑电图及头颅核磁改变的相关性;对动态脑电图及头颅核磁检查均异常的抽动障碍患儿具体分析其临床特点。结果:1)动态脑电图异常组抽动障碍患儿之耶鲁评分高于正常组(P<0.05),病情越重(耶鲁评分越高),动态脑电图异常率越高;2)头颅核磁异常组抽动患儿耶鲁评分亦高于正常组,但差异不具有统计学意义(P=0.077);3)动态脑电图及头颅核磁均异常患儿中,脑电异常以慢波为主,头颅核磁异常以脑室增宽或不对称及异常信号灶为主。结论:动态脑电图与抽动障碍患儿病情严重程度相关,可作为病情评估的客观标准之一;头颅核磁检查情况与抽动障碍严重程度相关性有待进一步研究证实。
Objective： To explore the relationship between the severities of tic disorder, indicated with YGTSS scores, and the resuits of ambulatory electroencephalogram and brain MRI. Methods： Data of the YGTSS scores, ambulatory electroencephalogram and brain MRI from 125 tic disorder cases were adopted. The 125 cases were divided into normal and abnormal groups according to the resuits of their ambulatory electroencephalogram and brain MRI. Then the average YGTSS scores between the groups were compared. To explore the relationship between the severities of tic disorder, all the cases were divided into three groups, mild, moderate and severe one according to their YGTSS scores, and their abnormal rates of the ambulatory electroencephalogram and brain MRI were compared accordingly. The clinical characteristics of 10 cases with both abnormal ambulatory electroencephalogram and brain MRI were listed and analyzed. Results： 1） The YGTSS scores in the abnormal ambulatory electroencephalogram group were higher than those in the normal one （P〈0.05）. The severer the case, or the higher the YGTSS score, the higher the ambulatory electroencephalogram abnormal rate. 2） The YGTSS scores in the abnormal brain MRI group were higher than those in the normal one, too. However, there was no statistical difference between the two groups （P=0.077）. 3） As to the cases with both abnormal ambulatory electroencephalogram and brain MRI, the results of ambulatory electroencephalogram were mainly slow waves, while those of brain MRI were expanded or asyrrunetry ventricles. Conclusions： Result of AEEG is related with the severity of tic disorder, thus, it can be used to assess tic disorder. However, the relationship between the brain MRI and the severity of tic disorder needs further investigation.
作者
秦丽萍
张欣
姜科宇
朱鹏程
吴敏
QIN Li-ping ZHANG Xin JIANG Ke-yu ZHU Peng-cheng WU Min(Department of Traditional Chinese Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Meclicine)
出处
《现代生物医学进展》
CAS
2016年第35期6835-6838,共4页
Progress in Modern Biomedicine
基金
国家中医药管理局"十二五"重点专科项目
国家卫生部重点专科建设项目(ZJ0901EK013)
上海市中西医结合临床重大项目(ZY3-LCPT-2-2005)
上海市卫生和计划生育委员会中医药科研基金课题(2014LP013B)
上海市科学技术委员会医学引导类(中医)科技项目(15401934000)
