摘要
目的:探讨早期服用二甲双胍对妊娠肥胖患者妊娠糖尿病的预防作用及对胎儿体重影响。方法:选取我院收治的54例妊娠肥胖患者,参照随机数字表法分成两组,每组27例。对照组患者给予运动方案治疗,无药物干预;研究组患者在对照组基础上给予二甲双胍。分别于生产前后检测患者血清空腹血糖(FBG)、餐后两小时血糖(2hPG)、糖化血红蛋白(HbA1C)、胰岛素(INS)以及C肽水平,并比较产后妊娠糖尿病患病率及胎儿体重。结果:生产后,研究组妊娠糖尿病患病率及胎儿异常发生率较对照组明显降低(P<0.05);与生产前比较,研究组FBG、2hPG、HbA1C、血清INS以及C肽水平无明显差异(P>0.05),对照组FBG、2hPG、HbA1C、血清INS以及C肽水平显著升高(P<0.05)。两组不良反应的发生率比较差异无明显意义(P>0.05)。结论:早期服用二甲双胍能有效预防妊娠肥胖患者发生妊娠糖尿病,可保持胎儿体重正常增长。
Objective： To investigate the effect of early use of metformin on the preventive and fetal weight in obese patients with gestational diabetes meUitus. Methods： 54 obese patients with pregnancy from our hospital were selected and randomly divided into the control group and the experiment group with 27 cases in each groups. The control group were treated by exercise regimen and no drug intervention. The experiment group were treated on the base of the control group with Metformin. The serum FBG, 2hPG, HbA1C, INS and C peptide levels, and the prevalence of gestational diabetes mellitus and fetal weight were compared before and alter treatment. Resuits： The prevalence of gestational diabetes mellitus and the incidence of fetal abnormalities were lower in the experiment after production （P〈0.05）. Compared with before production, there was no obvious difference on the the serum levels ofFBG, 2hPG, HbA1C, INS and C peptide （P〉0.05）. The serum levels ofFBG, 2hPG, HbA1C, INS and C peptide were higher in the control group （P〈0.05）. There was no significant difference in adverse reaction rates （P〉0.05）. Conclusion： Early administration of mefformin can effectively prevent pregnancy induced diabetes in obese patients with gestational diabetes mellitus, which can keep the normal development of the fetus.
作者
屈小洁
陈园园
李慧
庞妮妮
苏彦梓
QU Xiao-jie CHEN Yuan-yuan LI Hui PANG Ni-ni SU Yan-zi(Department of Obstetrics and Gynecology, Changan Xi＇an hospital, Xi＇an, Shaanxi, 710016, China Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xi＇an Medical University Xi＇an, Shaanxi, 710077, China)
出处
《现代生物医学进展》
CAS
2016年第35期6894-6897,共4页
Progress in Modern Biomedicine
基金
陕西省自然科学基金项目(2008c252)
关键词
二甲双胍
妊娠肥胖
妊娠糖尿病
胎儿体重
Metformin
Gestational obesity
Gestational diabetes mellitus
Fetal weight
