摘要
目的:探讨硫酸镁联合酚妥拉明及硝普钠在治疗重度子痫前期并发左心衰竭中的疗效。方法:收集2008年1月至2015年12月在我院住院的重度子痫合并左心衰竭的患者48例,其中2008年1月至2012年12月收治的24例患者采用单独硫酸镁治疗方法,为对照组,2013年1月至2015年12月收治的24例患者采用硫酸镁联合酚妥拉明及硝普钠的治疗方法,为观察组,并观察两组患者在治疗后的疗效、血气情况及相关检验结果。结果:经过治疗观察组患者较对照组的疗效有明显改善;观察组治疗后心率(HR)、呼吸(RR)、收缩压(SBP)、舒张压(DBP)较对照组显著下降,观察组治疗后Pa CO2、Pa O2、Sa O2较对照组显著上升;观察组治疗后血小板较对照组显著升高,观察组治疗后,丙氨酸氨基转移酶(ALT)、谷草转氨酶(AST)、尿素氮、肌酐、尿酸、尿蛋白较对照组显著下降。以上差异均具有统计学意义(P<0.05)。结论:硫酸镁联合酚妥拉明及硝普钠在治疗重度子痫前期并发左心衰竭中治疗具有良好的疗效,能够有效改善患者的血气及相关检验指标情况,具有一定的临床推广价值。
Objective： To investigate the clinical efficacy of magnesium sulfate combined with phentolamine and sodium nitroprusside in treatment of severe preeclampsia with the left heart failure. Methods： 46 cases of severe preeclampsia with left heart failure patients were collected and divided into two groups. The 24 patients in control group were treated with magnesium sulfate alone, and the 24 patients in observation group were treated with magnesium sulfate combined phentolamine and sodium nitrate. The curative effect of two groups after treatment was observed, and the blood gas situation and relevant test results were detected and compared. Results： After treatment the curative effect of observation group was superior to the control group with statistical significance. After treatment, the heart rate （HR）, respiratory （RR）, systolic blood pressure （SBP）, diastolic blood pressure （DBP） in observation group was decreased more obviously than that of the control group, and the level of PaCO2, PaO2, SaO2 in observation group was increased more significantly than that of control group. The platelet was more significantly increased in observation group than that of the control group after treatment, and the level of alanine aminotransferase （ALT）, aspertate aminotransferase （AST）, urea nitrogen, creatinine, uric acid, urine protein was decreased more obviously than that of control group. All the above differences were statistically significant （P〈0.05）. Conclusions： Joint phentolamine and magnesium sulfate, sodium nitrate has good curative effect in the treatment of severe preeclampsia complicated with left heart failure, it can effectively improve the patient＇s blood gas indexes and related tests, and has certain clinical value.
作者
温永芬
鲁照明
涂素华
唐宏
田丽
杨鹏
WEN Yong-fen LU Zhao-min TU Su-hua TANG Hong TIAN Li YANG Peng(The Affiliated Hospital of Sichuan Medical University, Luzhou, Sichuan, 646000, China Fourth Military Medical University, Xi＇an, Shaanxi, 710032, China)
出处
《现代生物医学进展》
CAS
2016年第36期7070-7073,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81072393
81102202)
关键词
硫酸镁
酚妥拉明
硝普钠
重度子痫前期
左心衰竭
Magnesium Sulfate
Phentolamine
Sodium Nitroprusside
Severe Preeclampsia
Left heart failure
