摘要
目的紫杉醇注射液不良反应的预防及处理。方法回顾性分析医院2012年6月-2015年6月采用紫杉醇注射液治疗恶性肿瘤患者80例的临床资料,将剂量为紫杉醇注射液135~175 mg/m2加入浓度为0.9%氯化钠溶液中配制成500 ml的溶液,采用特制材料的输液瓶及输液器进行静脉滴注。观察不良反应发生情况。结果 80例恶性肿瘤患者中,出现不良反应23例(28.75%)。不良反应主要包括骨髓抑制10例,消化道反应8例,肌肉疼痛2例,过敏反应2例及神经毒性1例。结论使用紫杉醇药物时应规范用药标准,严密监测患者生命体征,避免患者出现严重的不良反应。
Objective To analysis the prevention and treatment of adverse effects on paclitaxel injection. Methods Retrospectively analyzed the clinical date of 80 cases patients with malignant neoplasms,treated by paclitaxel injection,from June 2012 to June 2015. Mix paclitaxel injection 135 ~ 175 mg / m2 and 0. 9% sodium chloride solution into 500 ml solution.Used a special material infusion bottle and infusion device for intravenous infusion. Results In 80 cases patients with malignant neoplasms,23 cases patients（ 28. 75%） with adverse reactions. Adverse reactions included 10 cases of bone marrow suppression,8 cases of digestive tract reaction,2 cases of muscle pain,2 cases of allergic reaction,1 case of neurotoxicity. Conclusion When using paclitaxel drugs should be standard drug use standards. Vital signs is closely monitored to avoid serious adverse reactions.
作者
张清
ZHANG Qing(Department of Pharmacy, The People＇s Hospital of Lianshui County, Jiangsu Province, Lianshui 223400, Chin)
出处
《临床合理用药杂志》
2017年第1期5-6,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
紫杉醇注射液
不良反应
预防
Paclitaxel injection
Adverse reactions
Prevention
