摘要
目的：分析非甾体类抗炎药对高龄宫颈癌手术患者术后吗啡镇痛效果的影响。方法：选择2010年1月～2015年5月在我院就诊的高龄宫颈癌患者96例，按照随机数表法将所有患者分为研究组（48例）和对照组（48例）。两组患者在术后注射吗啡镇痛，而研究组在此基础上静脉注射非甾体类抗炎药酮咯酸氨丁三醇，对照组患者注射与研究组等量的生理盐水。术后1h、6h、12h、24h时，用数字等级评定量表（NRS）对两组患者的术后疼痛效果进行评分，两组患者的镇静程度用Ramsay评分，记录两组患者术后的不良情况，记录患者手术后24h镇痛泵按压总次数以及有效次数，计算两组患者的吗啡用量。结果：术后1h、6h时研究组患者的NRS评分明显低于对照组患者。术后6h、12h、24h时研究组患者的镇静程度（Ramsay）评分明显低于对照组患者，术后24h内研究组患者的经静脉患者自控镇痛（PCIA）总数、PCIA有效次数以及吗啡用量等明显少于对照组患者，差异有统计学意义（P〈0．05）。研究组中3例患者出现恶心呕吐，对照组患者5例出现恶心呕吐，对照组患者7例出现瘙痒，研究组无患者出现瘙痒，差异有统计学意义（P〈0．05）。结论：静脉注射非甾体类抗炎药酮咯酸氨丁三醇能够减少吗啡的用量，有效提高高龄宫颈癌根治术患者的镇痛效果，且减少术后不良反应效果良好，值得临床推广。
OBJECTIVE ： To evaluate the analgesia effects of intravenous infusion of a non steroidal anti - inflammatory drug and morphine after surgery for cervical cancer. METHODS： 96 patients with cervical cancer treated in our hospital were selected from Jan- uary 2010 to May 2014. All of patients were divided into study group （48 cases） and control group （48 cases） according to a random number table method. The two groups were intravenous morphine after surgery, while on the basis of intravenous Ketorolac Tromethamine, study group intravenous equivalent doses physiological saline. Mter 1h, 6h, 12h, 24h, using NRS scale the effect on pain in two group and using the Ramsay evaluate the degree of sedation in two groups. The adverse, the pump press total number and the effective number of times of patients after operation of 24b analgesia were recorded. Morphine of two groups were celculated. RESULTS： At lh and 6h after operation MRA score in study group was significantly lower than that in control group. After 6h, 12h and 24h Ramsay score in study group was significantly lower than that in control group. 24h after operation in the study group, PCIA and total effective number of morphine were obviously less than those in the control group. There was statistically significant difference （P 〈0. 05）. 3 patients in study group had nausea and vomiting, and in contrul group 5 cases had. In control group 7 patients had itching. There was statistical significant difference. CONCLUSION： Intravenous injection of non steroidal anti - inflammatory drug ketorolac ammonia butyl alcohol three can reduce the morphine amount and effectively improve the curative effect of analgesia in pa-tients with cervical cancer and reduce postoperative adverse reaction.
出处
《国际老年医学杂志》
2017年第1期33-36,共4页
International Journal of Geriatrics
关键词
非甾体类抗炎药
宫颈癌手术
吗啡
镇痛效果
Non steroidal anti -inflammatory drugs
Cervical cancer operation
Morphine
Analgesia effect
