摘要
目的调查长病程继发性癫痫患者生活质量及其影响因素。方法对2013年1月至2016年1月于佛山市第二人民医院门诊及住院的76例病程≥10年的继发性癫痫患者生活质量进行调查。采用癫痫患者生活质量量表-31(QOLIE-31)评估患者的生活质量、评估患者基本特征及各量表评分对继发性癫痫患者生活质量的影响。同时选取76例健康自愿者作为健康对照组。结果病程≥10年的继发性癫痫患者QOLIE-31总分为(68.27±8.62)分,明显低于健康对照组的(92.45±10.08)分,差异有统计学意义(P<0.05);影响QOLIE-31总分的相关因素包括年龄(r=0.412,P=0.021)、病程(r=-0.353,P=0.006)、不良反应量表(SEP)评分(r=-0.364,P=0.000)、蒙特利尔认知评估量表(Mo CA)评分(r=0.815,P=0.000)、斯特鲁普(Stroop)效应得分(r=0.754,P=0.005)、词汇流畅性得分(r=0.423,P=0.000)、汉密尔顿焦虑量表(HAMA)评分(r=-0.506,P=0.000)、贝克抑郁问卷(BDI)评分(r=-0.440,P=0.001);进一步分析发现对QOLIE-31得分有影响的独立危险因素有SEP评分(r=-0.356,P=0.017)、Mo CA评分(r=0.202,P=0.007)及BDI评分(r=-0.248,P=0.076)。结论长病程继发性癫痫患者生活质量明显下降,其中SEP评分、Mo CA评分、BDI评分是影响癫痫患者远期生活质量的独立危险因素,SEP评分的独立贡献远大于其他两项,提示临床上应重点注意病程≥10年的患者治疗药物方案的选择。
Objective To investigate the quality of life and its related factors in secondary epilepsy patients with long-term duration. Methods The quality of life in 76 secondary epilepsy patients with long-term disease duration（duration≥10 years, as epilepsy group） from January 2013 to January 2016 in the Second People＇s Hospital of Foshan was investigated and analyzed. The quality of life in secondary epilepsy patients was measured with Quality of Life in Epilepsy Inventory-31（QOLIE-31）. The effects of the patient＇s clinical characteristics and the scales＇ scores were evaluated. Seventy-six healthy volunteers were selected as control group. Results The mean QOLIE-31 score in epilepsy group was significantly lower than that in the control group,（68.27±8.62） vs（92.45±10.08）, P〈0.05. The related factors of QOLIE-31 score included age（r=0.412, P=0.021）, duration（r=-0.353, P=0.006）, SEP score（r=-0.364, P=0.000）,Montreal Cognitive Assessment（Mo CA） score（r=0.815, P=0.000）, Stroop effect score（r=0.754, P=0.005）, verbal fluency score（r=0.423, P=0.000）, Hamilton Anxiety Scale（HAMA） score（r=-0.506, P=0.000） and BDI score（r=-0.440, P=0.001）. Further study found that the independent risk factors of QOLIE-31 score included SEP score（r=-0.356, P=0.017）,Mo CA score（r=0.202, P=0.007） and HAMA score（r=-0.248, P=0.076）. Conclusion The quality of life in patients with long term secondary epilepsy was significantly decreased. The SEP score, the Mo CA score and BDI score were the independent risk factors, and the independent contribution of SEP score was far outweigh than the other two. It suggested that we should focus on the selection of therapeutic drugs in secondary epilepsy patients with long-term duration.
作者
卢颖瑜
王金良
巫碧佳
秦兴华
王鹏
LU Ying-yu WANG Jing-liang WU Bi-jia QIN Xing-hua WANG Peng(Department of Neurology, the Second People＇s Hospital of Foshan, Foshan 528000, Shandong, CHIN)
出处
《海南医学》
CAS
2017年第2期319-322,共4页
Hainan Medical Journal
关键词
长病程
继发性癫痫
生活质量
影响因素
Long term
Secondary epilepsy
Quality of life
Related factors
