摘要
目的探讨苦碟子注射液联合替罗非班对颅内动脉狭窄支架置入术后血栓形成的影响。方法将行颅内动脉狭窄支架植入术的58例患者随机分为治疗组和对照组各29例,术中2组均给予替罗非班治疗,术后对照组给予常规用药治疗,治疗组在对照组治疗基础上给予苦碟子注射液静滴,观察2组治疗后血栓形成情况,统计2组临床疗效。结果治疗组血栓总发生率显著低于对照组(P<0.05)。2组治疗后神经功能缺损评分及Pro MMP-2、MMP-2水平均明显降低(P均<0.05),且治疗组明显低于对照组(P均<0.05)。治疗组康复、再梗、死亡例数均少于对照组(P均<0.05)。结论苦碟子注射液联合替罗非班可降低颅内动脉狭窄支架置入术后血栓总发生率及Pro MMP-2、MMP-2水平,改善患者的神经功能,降低再梗率和病死率。
Objective It is to observe the effect of Kudiezi injection combined with tirofiban on thrombosis after carotid stenting surges for intracranial artery stenosis. Methods Fifty-eight patients undergoing carotid stenting surges for intracranial artery stenosis were randomly divided into treatment group and control group, each group had 29 cases. Both groups were treated with tirofiban during operation, and after operation the control group was given routine therapy, the treatment group was given Kudiezi injection by intravenous drip on the basis of treatment in control group. Thrombosis was observed after treatment in both groups, and the curative effects were compared. Results The total incidence rate of thrombosis in treatment group was higher than that in control group（ P〈 0. 05 ） . The scores of nerve function defect grade and the levels of Pro MMP - 2 and MMP -2 were significantly decreased after treatment in both groups（P〈0. 05） , and the decrease in treatment group was more significant than that in control group （ P〈 0.05 ） . The prognosis of patients in treatment group was better than that in control group （ P〈 0. 05 ） . Conclusion Kudiezi injection combined with tirofiban could reduce total incidence of thrombosis and levels of Pro MMP - 2 and MMP - 2 after carotid stenting surgery for intracranial artery stenosis,improve the patients nerve function ,reduce reinfarction rate and fatality rate.
出处
《现代中西医结合杂志》
CAS
2017年第5期485-487,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
