摘要
目的探讨噻托溴铵治疗慢性阻塞性肺疾病(COPD)合并支气管扩张的临床疗效。方法选取2015年4月—2016年2月中江县人民医院收治的COPD合并支气管扩张患者40例,采用随机数字表法分成对照组(n=19)和ヌ见察组(n=21)。对照组患者采用常规治疗方案,观察组患者在常规治疗的基础上采用噻托溴铵治疗。比较两组患者治疗前后的肺功能指标(包括第1秒用力呼气末容积(FEV_1)、用力肺活量(FVC)、第1秒用力呼气末容积与用力肺活量比值(FEV_1/AFVC)、深吸气量(IC))、血气分析指标[包括血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)]、临床症状评分和运动耐力[包括咳嗽、气促、啰音评分及6 min歩行距离]以及不良反应发生情况。结果治疗前两组患者FEV_1,FVC、FEV_1/FVC,IC比较,差异无统计学意义(P>0.05);治疗后观察组患者FEV_1、FVC,FEV_1/FVC,IC高于对照组(P<0.05)。治疗前两组患者PaO_2、PaCO_2比较,差异无统计学意义(P>0.05);治疗后观察组患者PaO_2高于对照组,PaCO_2低于对照组(P<0.05)。治疗前两组患者咳嗽、气促、啰音评分及6 min步行距离比较,差异无统计学意义(P>0.05);治疗后观察组患者咳嗽、气促、啰音评分低于对照组,6 min步行距离长于对照组(P<0.05)。治疗期间两组患者均未出现严重不良反应。结论噻托溴铵治疗COPD合并支气管扩张的疗效确切,可有效改善患者肺功能和血气分析指标,缓解临床症状,且无明显不良反应。
Objective To explore the clinical effect of tiotropium bromide in treating chronic obstructive pulmonary disease （COPD） complicated with bronchiectasis. Methods A total of 40 COPD patients complicated with bronchiectasis were selected in Peopled Hospital of Zhongjiang City form April 2015 to February 2016, and they were divided into observation group （n =21） and control group （n = 19） by random table method. Patients of control group were given conventional therapy, while patients of observation group were treated with tiotropium bromide on the basis of conventional therapy. The lung function index （including FEV1 , FVC , FEV1/FVC , IC ） , blood gas analysis index （including PaO2, PaCO2） , clinical symptoms scores and exercise tolerance （including cough score, dyspnea score, rale score, 6 min walking distance）, and the adverse reaction conditions were compared between the two groups. Results No statistically significant differences of FEV1 , FVC , FEV1/FVC ,IC was found before the treatment （ P 〉 0. 05 ）. The FEV1 , FVC , FEV1/ FVC , IC of observation group were statistically significantly higher than that of control group after the treatment （P 〈 0. 05）. No statistically significant differences of PaO2,PaCO2 was found before the treatment （P 〉 0. 05）. The PaO2 of observation group was statistically significantly higher than that of control group,the PaCO2 of observation group was statistically significantly lower than that of control group after the treatment （P 〈 0. 05 ）. No statistically significant differences of cough score, dyspnea score, rale score, 6 min walking distance was found before the treatment （P 〉 0. 05 ）. The cough score, dyspnea score, rale score of observation group were statistically significantly lower than that of control group, the 6 min walking distance of observation group was statistical ly significantly longer than that of control group after the treatment （P 〈 0. 05）. There were no serious adverse reactions in the two groups during the treatment period. Conclusion The clinical effect of tiotropium bromide in treating COPD complicated with bronchiectasis is exactly, it can effectively improve the patient＇s lung function and blood gas analysis index , relieve clinical symptoms, and no obvious adverse reactions.
出处
《中国全科医学》
CAS
CSCD
北大核心
2016年第B12期176-178,共3页
Chinese General Practice
关键词
肺疾病
慢性阻塞性
支气管扩张症
噻托溴铵
治疗结果
Pulmonary disease,chronic obstructive
Bronchiectasis
Tiotropium bromide
Treatment outcome
